Urinary interleukin-8 is elevated in urinary tract infections independently of the causative germs.

Creators: Oregioni, Olivier; Delaunay, Pascal; Bruna, Pascal; Gaudart, Alice; Lemichez, Emmanuel; Boquet, Patrice; Landraud, Luce

Others:: Laboratoire de Bactériologie [CHU Nice] ; Centre Hospitalier Universitaire de Nice (CHU Nice)-Hôpital Archet 2 [Nice] (CHU); Laboratoire de Parasitologie-Mycologie ; Centre Hospitalier Universitaire de Nice (CHU Nice); Toxines bactériennes dans la relation hôtes-pathogènes ; Université Nice Sophia Antipolis (1965 - 2019) (UNS) ; COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-IFR50-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA)

Description

Interleukin-8 elevation in urine during urinary tract infections (UTIs) has been documented for different uropathogenic germs in 85 patients. We showed that for 17 different isolates, IL-8 was increased in 92% of UTIs with an average value of 627 pg/ml for infected, as compared to 45 pg/ml for uninfected patients. We suggest that the high negative predictive value of the IL-8 urine assay could be useful to eliminate UTIs in routine screenings.

Urinary interleukin-8 is elevated in urinary tract infections independently of the causative germs.

Description

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