Published 2023
| Version v1
Publication
Long-Term Efficacy of Mepolizumab at 3 Years in Patients with Severe Asthma: Comparison with Clinical Trials and Super Responders
Creators
- Bagnasco, Diego
- Nicola, Stefania
- Testino, Elisa
- Brussino, Luisa
- Pini, Laura
- Caminati, Marco
- Piccardo, Federica
- Canevari, Rikki Frank
- Melissari, Laura
- Ioppi, Alessandro
- Guastini, Luca
- Lombardi, Carlo
- Milanese, Manlio
- Losa, Francesca
- Robbiano, Michela
- De Ferrari, Laura
- Riccio, Anna Maria
- Guida, Giuseppe
- Bonavia, Marco
- Fini, Donatella
- Balbi, Francesco
- Caruso, Cristiano
- Paggiaro, Pierluigi
- Blasi, Francesco
- Heffler, Enrico
- Paoletti, Giovanni
- Canonica, Giorgio Walter
- Senna, Gianenrico
- Passalacqua, Giovanni
- On Behalf Of Sani, null
Contributors
Others:
- Bagnasco, Diego
- Nicola, Stefania
- Testino, Elisa
- Brussino, Luisa
- Pini, Laura
- Caminati, Marco
- Piccardo, Federica
- Canevari, Rikki Frank
- Melissari, Laura
- Ioppi, Alessandro
- Guastini, Luca
- Lombardi, Carlo
- Milanese, Manlio
- Losa, Francesca
- Robbiano, Michela
- De Ferrari, Laura
- Riccio, Anna Maria
- Guida, Giuseppe
- Bonavia, Marco
- Fini, Donatella
- Balbi, Francesco
- Caruso, Cristiano
- Paggiaro, Pierluigi
- Blasi, Francesco
- Heffler, Enrico
- Paoletti, Giovanni
- Canonica, Giorgio Walter
- Senna, Gianenrico
- Passalacqua, Giovanni
- On Behalf Of Sani, Null
Description
: The efficacy mepolizumab in severe asthmatic patients is proven in the literature. Primarily to study the effect of mepolizumab on exacerbations, steroid dependence, and the continuation of efficacy in the long term. Secondarily to evaluate the effect of the drug on nasal polyps. Analyzing data from SANI (Severe Asthma Network Italy) clinics, we observed severe asthmatic patients treated with mepolizumab 100 mg/4 weeks, for a period of 3 years. 157 patients were observed. Exacerbations were reduced from the first year (-84.6%) and progressively to 90 and 95% in the second and third ones. Steroid-dependent patients decreased from 54% to 21% and subsequently to 11% in the second year and 6% in the third year. Patients with concomitant nasal polyps, assessed by SNOT-22, showed a 49% reduction in value from baseline to the third year. The study demonstrated the long-term efficacy of mepolizumab in a real-life setting.
Additional details
Identifiers
- URL
- https://hdl.handle.net/11567/1155259
- URN
- urn:oai:iris.unige.it:11567/1155259
Origin repository
- Origin repository
- UNIGE