Cancer-testis Antigen FATE1 Expression in Adrenocortical Tumors Is Associated with A Pervasive Autoimmune Response and Is A Marker of Malignancy in Adult, but Not Children, ACC

Creators: Doghman-Bouguerra, Mabrouka; Finetti, Pascal; Durand, Nelly; Parise, Ivy Zortéa; Sbiera, Silviu; Cantini, Giulia; Canu, Letizia; Hescot, Ségolène; Figueiredo, Mirna; Komechen, Heloisa; Sbiera, Iuliu; Nesi, Gabriella; Paci, Angelo; Al Ghuzlan, Abir; Birnbaum, Daniel; Baudin, Eric; Luconi, Michaela; Fassnacht, Martin; Figueiredo, Bonald; Bertucci, François; Lalli, Enzo

Others:: Institut de pharmacologie moléculaire et cellulaire (IPMC) ; Université Nice Sophia Antipolis (1965 - 2019) (UNS) ; COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA); Laboratoire International Associé "Neogenex" (LIA Neogenex) ; Université Nice Sophia Antipolis (1965 - 2019) (UNS) ; COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-St Jude Children's Research Hospital-Hôpital Pequeño Principe; Centre de Recherche en Cancérologie de Marseille (CRCM) ; Aix Marseille Université (AMU)-Institut Paoli-Calmettes ; Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS); Pelé Pequeno Príncipe Research Institute [Curitiba, Brazil]; University of Würzburg; Università degli Studi di Firenze = University of Florence (UniFI); Département de médecine nucléaire (Institut Curie, Saint-Cloud) ; Institut Curie [Paris]; University Hospital of Würzburg; Institut Gustave Roussy (IGR); Département de biologie et pathologie médicales [Gustave Roussy] ; Institut Gustave Roussy (IGR)

Description

The SF-1 transcription factor target gene FATE1 encodes a cancer-testis antigen that has an important role in regulating apoptosis and response to chemotherapy in adrenocortical carcinoma (ACC) cells. Autoantibodies directed against FATE1 were previously detected in patients with hepatocellular carcinoma. In this study, we investigated the prevalence of circulating anti-FATE1 antibodies in pediatric and adult patients with adrenocortical tumors using three different methods (immunofluorescence, ELISA and Western blot). Our results show that a pervasive anti-FATE1 immune response is present in those patients. Furthermore, FATE1 expression is a robust prognostic

Abstract

International audience

Cancer-testis Antigen FATE1 Expression in Adrenocortical Tumors Is Associated with A Pervasive Autoimmune Response and Is A Marker of Malignancy in Adult, but Not Children, ACC

Description

Abstract

Additional details