IC50 of trifluoperazine and RMI 12330A for the Theophylline and Phloretin - lnduced lncrease in Intestinal D-Galactose Accumulation

The effect of trifluoperazine and RMI 12330A on D-Galactose accumulation was studied in isolated rat intestinal mucosa. Both drugs inhibited the theophylline and phloretin-induced increase in tissue sugar accumulation in a concentration-dependent fashion, with IC50 values close to 10- 6 M. These findings suggest that calmodulin might mediate the theophylline and phloretin actions on galactose transpon in intact rat ilcum.