Published May 24, 2016
| Version v1
Publication
Microglia-secreted galectin-3 acts as a toll-like receptor 4 ligand and contributes to microglial activation
Creators
- Burguillos García, Miguel Ángel
- Svensson, Martina
- Schulte, Tim
- Boza Serrano, Antonio
- García Quintanilla, Alberto
- Kavanagh, Edel T.
- Santiago Pavón, Martiniano
- Viceconte, Nikenza
- Oliva Martín, María José
- Osman, Ahmed Mohamed
- Salomonsson, Emma
- Amar, Lahouari
- Persson, Annette
- Blomgren, Klas
- Achour, Adnane
- Englund, Elisabet
- Leffler, Hakon
- Venero Recio, José Luis
- Joseph, Bertrand
- Deierborg, Tomas
Contributors
Description
Inflammatory response induced by microglia plays
a critical role in the demise of neuronal populations
in neuroinflammatory diseases. Although the role of
toll-like receptor 4 (TLR4) in microglia's inflammatory
response is fully acknowledged, little is known about
endogenous ligands that trigger TLR4 activation.
Here, we report that galectin-3 (Gal3) released by
microglia acts as an endogenous paracrine TLR4
ligand. Gal3-TLR4 interaction was further confirmed
in a murine neuroinflammatory model (intranigral
lipopolysaccharide [LPS] injection) and in human
stroke subjects. Depletion of Gal3 exerted neuroprotective
and anti-inflammatory effects following
global brain ischemia and in the neuroinflammatory
LPS model. These results suggest that Gal3-dependent-
TLR4 activation could contribute to sustained
microglia activation, prolonging the inflammatory
response in the brain
Additional details
Identifiers
- URL
- https://idus.us.es/handle/11441/41543
- URN
- urn:oai:idus.us.es:11441/41543
Origin repository
- Origin repository
- USE