Published June 3, 2020
| Version v1
Publication
Synthesis and Biological Evaluation of Modified 2-Deoxystreptamine Dimers
Description
Aminoglycosides are powerful antibiotics, but the emergence of resistant bacterial strains has prompted the search for analogues with better pharmacological profiles. The synthesis of 2-deoxystreptamine (2-DOS) dimers linked by polyamines and analogues based on furylcarbopeptoid skeletons is described. Potent and selective ligands for bacterial 16S rRNA were identified using microarray techniques by determining the affinity of these derivatives toward bacterial and human ribosomal RNAs
Additional details
Identifiers
- URL
- https://idus.us.es/handle//11441/97381
- URN
- urn:oai:idus.us.es:11441/97381
Origin repository
- Origin repository
- USE