Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways
- Creators
- Duffy, David L
- Zhu, Gu
- Li, Xin
- Sanna, Marianna
- Iles, Mark M
- Jacobs, Leonie C
- Evans, David M
- Yazar, Seyhan
- Beesley, Jonathan
- Law, Matthew H
- Kraft, Peter
- Visconti, Alessia
- Taylor, John C
- Lui, Fan
- Wright, Margaret J
- Henders, Anjali K
- Bowdler, Lisa
- Glass, Dan
- Ikram, Arfan M
- Uitterlinden, André G
- Madden, Pamela A
- Heath, Andrew C
- Nelson, Elliot C
- Green, Adele C
- Chanock, Stephen
- Barrett, Jennifer H
- Brown, Matthew A
- Hayward, Nicholas K
- MacGregor, Stuart
- Sturm, Richard A
- Hewitt, Alex W
- Kayser, Manfred
- Hunter, David J
- Newton Bishop, Julia A
- Spector, Timothy D
- Montgomery, Grant W
- Mackey, David A
- Smith, George Davey
- Nijsten, Tamar E
- Bishop, D Timothy
- Bataille, Veronique
- Falchi, Mario
- Han, Jiali
- Martin
- Nicholas G
- Lee JE
- Brossard M
- Moses EK
- Song F
- Kumar R
- Easton DF
- Pharoah PDP
- Swerdlow AJ
- Kypreou KP
- Harland M
- Randerson-Moor J
- Akslen LA
- Andresen PA
- Avril MF
- Azizi E
- Scarrà GB
- Brown KM
- Dębniak T
- Elder DE
- Fang S
- Friedman E
- Galan P
- Ghiorzo P
- Gillanders EM
- Goldstein AM
- Gruis NA
- Hansson J
- Helsing P
- Hočevar M
- Höiom V
- Ingvar C
- Kanetsky PA
- Chen WV
- Landi MT
- Lang J
- Lathrop GM
- Lubiński J
- Mackie RM
- Mann GJ
- Molven A
- Novaković S
- Olsson H
- Puig S
- Puig-Butille JA
- Radford-Smith GL
- van der Stoep N
- van Doorn R
- Whiteman DC
- Craig JE
- Schadendorf D
- Simms LA
- Burdon KP
- Nyholt DR
- Pooley KA
- Orr N
- Stratigos AJ
- Cust AE
- Ward SV
- Schulze HJ
- Dunning AM
- Demenais F
- Amos CI.
- Others:
- Duffy, David L
- Zhu, Gu
- Li, Xin
- Sanna, Marianna
- Iles, Mark M
- Jacobs, Leonie C
- Evans, David M
- Yazar, Seyhan
- Beesley, Jonathan
- Law, Matthew H
- Kraft, Peter
- Visconti, Alessia
- Taylor, John C
- Lui, Fan
- Wright, Margaret J
- Henders, Anjali K
- Bowdler, Lisa
- Glass, Dan
- Ikram, Arfan M
- Uitterlinden, André G
- Madden, Pamela A
- Heath, Andrew C
- Nelson, Elliot C
- Green, Adele C
- Chanock, Stephen
- Barrett, Jennifer H
- Brown, Matthew A
- Hayward, Nicholas K
- Macgregor, Stuart
- Sturm, Richard A
- Hewitt, Alex W
- Kayser, Manfred
- Hunter, David J
- Newton Bishop, Julia A
- Spector, Timothy D
- Montgomery, Grant W
- Mackey, David A
- Smith, George Davey
- Nijsten, Tamar E
- Bishop, D Timothy
- Bataille, Veronique
- Falchi, Mario
- Han, Jiali
- Martin,
- Nicholas, G
- Lee, Je
- Brossard, M
- Moses, Ek
- Song, F
- Kumar, R
- Easton, Df
- Pharoah, Pdp
- Swerdlow, Aj
- Kypreou, Kp
- Harland, M
- Randerson-Moor, J
- Akslen, La
- Andresen, Pa
- Avril, Mf
- Azizi, E
- Scarrà, Gb
- Brown, Km
- Dębniak, T
- Elder, De
- Fang, S
- Friedman, E
- Galan, P
- Ghiorzo, P
- Gillanders, Em
- Goldstein, Am
- Gruis, Na
- Hansson, J
- Helsing, P
- Hočevar, M
- Höiom, V
- Ingvar, C
- Kanetsky, Pa
- Chen, Wv
- Landi, Mt
- Lang, J
- Lathrop, Gm
- Lubiński, J
- Mackie, Rm
- Mann, Gj
- Molven, A
- Novaković, S
- Olsson, H
- Puig, S
- Puig-Butille, Ja
- Radford-Smith, Gl
- van der Stoep, N
- van Doorn, R
- Whiteman, Dc
- Craig, Je
- Schadendorf, D
- Simms, La
- Burdon, Kp
- Nyholt, Dr
- Pooley, Ka
- Orr, N
- Stratigos, Aj
- Cust, Ae
- Ward, Sv
- Schulze, Hj
- Dunning, Am
- Demenais, F
- Amos, Ci.
Citation
Description
The total number of acquired melanocytic nevi on the skin is strongly correlated with melanoma risk. Here we report a meta-analysis of 11 nevus GWAS from Australia, Netherlands, UK, and USA comprising 52,506 individuals. We confirm known loci including MTAP, PLA2G6, and IRF4, and detect novel SNPs in KITLG and a region of 9q32. In a bivariate analysis combining the nevus results with a recent melanoma GWAS meta-analysis (12,874 cases, 23,203 controls), SNPs near GPRC5A, CYP1B1, PPARGC1B, HDAC4, FAM208B, DOCK8, and SYNE2 reached global significance, and other loci, including MIR146A and OBFC1, reached a suggestive level. Overall, we conclude that most nevus genes affect melanoma risk (KITLG an exception), while many melanoma risk loci do not alter nevus count. For example, variants in TERC and OBFC1 affect both traits, but other telomere length maintenance genes seem to affect melanoma risk only. Our findings implicate multiple pathways in nevogenesis.
Additional details
- URL
- http://hdl.handle.net/11567/935473
- URN
- urn:oai:iris.unige.it:11567/935473
- Origin repository
- UNIGE