Published 2022
| Version v1
Publication
Progressive brachial plexus enlargement in hereditary transthyretin amyloidosis
Creators
- Salvalaggio, Alessandro
- Coraci, Daniele
- Obici, Laura
- Cacciavillani, Mario
- Luigetti, Marco
- Mazzeo, Anna
- Pastorelli, Francesca
- Grandis, Marina
- Cavallaro, Tiziana
- Bisogni, Giulia
- Lozza, Alessandro
- Gemelli, Chiara
- Gentile, Luca
- Russo, Massimo
- Ermani, Mario
- Fabrizi, Gian Maria
- Plasmati, Rosaria
- De Napoli, Federica
- Campagnolo, Marta
- Castellani, Francesca
- Salvi, Fabrizio
- Fenu, Silvia
- Devigili, Grazia
- Pareyson, Davide
- Gasparotti, Roberto
- Rapezzi, Claudio
- Martinoli, Carlo
- Padua, Luca
- Briani, Chiara
Contributors
Others:
- Salvalaggio, Alessandro
- Coraci, Daniele
- Obici, Laura
- Cacciavillani, Mario
- Luigetti, Marco
- Mazzeo, Anna
- Pastorelli, Francesca
- Grandis, Marina
- Cavallaro, Tiziana
- Bisogni, Giulia
- Lozza, Alessandro
- Gemelli, Chiara
- Gentile, Luca
- Russo, Massimo
- Ermani, Mario
- Fabrizi, Gian Maria
- Plasmati, Rosaria
- De Napoli, Federica
- Campagnolo, Marta
- Castellani, Francesca
- Salvi, Fabrizio
- Fenu, Silvia
- Devigili, Grazia
- Pareyson, Davide
- Gasparotti, Roberto
- Rapezzi, Claudio
- Martinoli, Carlo
- Padua, Luca
- Briani, Chiara
Description
: Axonal polyneuropathy is the main feature of hereditary transthyretin amyloidosis (ATTRv). Nerve morphological abnormalities have been reported, but longitudinal changes have never been assessed. We performed a prospective widespread nerve ultrasound evaluation and nerve cross-sectional area (CSA) was compared with baseline data in both ATTRv patients and pre-symptomatic carriers. Thirty-eight subjects were evaluated (mean follow-up 17.1 months), among them 21 had polyneuropathy while 17 were pre-symptomatic carriers. CSA significantly increased at brachial plexus in both groups (p = 0.008 and p = 0.012) pointing to progressive brachial plexus enlargement as a longitudinal biomarker of both disease progression and disease occurrence in pre-symptomatic carriers.
Additional details
Identifiers
- URL
- http://hdl.handle.net/11567/1089362
- URN
- urn:oai:iris.unige.it:11567/1089362
Origin repository
- Origin repository
- UNIGE