Does acute peripheral trauma contribute to idiopathic adult-onset dystonia?
- Creators
- Defazio G.
- Fabbrini G.
- Erro R.
- Albanese A.
- Barone P.
- Zibetti M.
- Esposito M.
- Pellicciari R.
- Avanzino L.
- Bono F.
- Eleopra R.
- Bertolasi L.
- Altavista M. C.
- Cotelli M. S.
- Ceravolo R.
- Scaglione C.
- Bentivoglio A. R.
- Cossu G.
- Coletti Moja M.
- Girlanda P.
- Misceo S.
- Pisani A.
- Mascia M. M.
- Ercoli T.
- Tinazzi M.
- Maderna L.
- Minafra B.
- Magistrelli L.
- Romano M.
- Aguggia M.
- Tambasco N.
- Castagna A.
- Cassano D.
- Berardelli A.
- Ferrazzano G.
- Lalli S.
- Silvestre F.
- Manganelli F.
- Di Biasio F.
- Marchese R.
- Demonte G.
- Santangelo D.
- Devigili G.
- Durastanti V.
- Turla M.
- Mazzucchi S.
- Petracca M.
- Oppo V.
- Barbero P.
- Morgante F.
- Di Lazzaro G.
- Squintani G.
- Modugno N.
- Others:
- Defazio, G.
- Fabbrini, G.
- Erro, R.
- Albanese, A.
- Barone, P.
- Zibetti, M.
- Esposito, M.
- Pellicciari, R.
- Avanzino, L.
- Bono, F.
- Eleopra, R.
- Bertolasi, L.
- Altavista, M. C.
- Cotelli, M. S.
- Ceravolo, R.
- Scaglione, C.
- Bentivoglio, A. R.
- Cossu, G.
- Coletti Moja, M.
- Girlanda, P.
- Misceo, S.
- Pisani, A.
- Mascia, M. M.
- Ercoli, T.
- Tinazzi, M.
- Maderna, L.
- Minafra, B.
- Magistrelli, L.
- Romano, M.
- Aguggia, M.
- Tambasco, N.
- Castagna, A.
- Cassano, D.
- Berardelli, A.
- Ferrazzano, G.
- Lalli, S.
- Silvestre, F.
- Manganelli, F.
- Di Biasio, F.
- Marchese, R.
- Demonte, G.
- Santangelo, D.
- Devigili, G.
- Durastanti, V.
- Turla, M.
- Mazzucchi, S.
- Petracca, M.
- Oppo, V.
- Barbero, P.
- Morgante, F.
- Di Lazzaro, G.
- Squintani, G.
- Modugno, N.
Description
Background: Acute peripheral trauma is a controversial risk factor for idiopathic dystonia. Materials and methods: We retrospectively analyzed data from the Italian Dystonia Registry regarding the occurrence of acute peripheral trauma severe enough to require medical attention in 1382 patients with adult-onset idiopathic dystonia and 200 patients with acquired adult-onset dystonia. Results: Patients with idiopathic and acquired dystonia showed a similar burden of peripheral trauma in terms of the number of patients who experienced trauma (115/1382 vs. 12/200, p = 0.3) and the overall number of injuries (145 for the 1382 idiopathic patients and 14 for the 200 patients with secondary dystonia, p = 0.2). Most traumas occurred before the onset of idiopathic or secondary dystonia but only a minority of such injuries (14 in the idiopathic group, 2 in the acquired group, p = 0.6) affected the same body part as that affected by dystonia. In the idiopathic group, the elapsed time between trauma and dystonia onset was 8.1 ± 9.2 years; only six of the 145 traumas (4.1%) experienced by 5/1382 idiopathic patients (0.36%) occurred one year or less before dystonia onset; in the acquired dystonia group, the two patients experienced prior trauma to the dystonic body part 5 and 6 years before dystonia development. Discussion and conclusion: Our data suggest that the contribution of peripheral acute trauma to idiopathic dystonia is negligible, if anything, and likely involves only a small subset of patients.
Additional details
- URL
- https://hdl.handle.net/11567/1041786
- URN
- urn:oai:iris.unige.it:11567/1041786
- Origin repository
- UNIGE