Published 2020
| Version v1
Publication
Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes
- Creators
- Marselli L.
- Piron A.
- Suleiman M.
- Colli M. L.
- Yi X.
- Khamis A.
- Carrat G. R.
- Rutter G. A.
- Bugliani M.
- Giusti L.
- Ronci M.
- Ibberson M.
- Turatsinze J. -V.
- Boggi U.
- De Simone P.
- De Tata V.
- Lopes M.
- Nasteska D.
- De Luca C.
- Tesi M.
- Bosi E.
- Singh P.
- Campani D.
- Schulte A. M.
- Solimena M.
- Hecht P.
- Rady B.
- Bakaj I.
- Pocai A.
- Norquay L.
- Thorens B.
- Canouil M.
- Froguel P.
- Eizirik D. L.
- Cnop M.
- Marchetti P.
- Others:
- Marselli, L.
- Piron, A.
- Suleiman, M.
- Colli, M. L.
- Yi, X.
- Khamis, A.
- Carrat, G. R.
- Rutter, G. A.
- Bugliani, M.
- Giusti, L.
- Ronci, M.
- Ibberson, M.
- Turatsinze, J. -V.
- Boggi, U.
- De Simone, P.
- De Tata, V.
- Lopes, M.
- Nasteska, D.
- De Luca, C.
- Tesi, M.
- Bosi, E.
- Singh, P.
- Campani, D.
- Schulte, A. M.
- Solimena, M.
- Hecht, P.
- Rady, B.
- Bakaj, I.
- Pocai, A.
- Norquay, L.
- Thorens, B.
- Canouil, M.
- Froguel, P.
- Eizirik, D. L.
- Cnop, M.
- Marchetti, P.
Description
Marselli et al. find that human β cell dysfunction induced by metabolic stresses is persistent or transient. RNA sequencing and eQTL analysis identify key pathways underlying failure and recovery. Type 2 diabetes β cells have several functional and molecular alterations and share specific transcriptomic traits of β cells with irreversible or rescuable damage.
Additional details
- URL
- http://hdl.handle.net/11567/1072802
- URN
- urn:oai:iris.unige.it:11567/1072802
- Origin repository
- UNIGE