Reactivation of Herpes Simplex Virus Type 1 (HSV-1) Detected on Bronchoalveolar Lavage Fluid (BALF) Samples in Critically Ill COVID-19 Patients Undergoing Invasive Mechanical Ventilation: Preliminary Results from Two Italian Centers
- Creators
- Giacobbe D. R.
- Di Bella S.
- Dettori S.
- Brucci G.
- Zerbato V.
- Pol R.
- Segat L.
- D'agaro P.
- Roman-Pognuz E.
- Friso F.
- Principe L.
- Lucangelo U.
- Ball L.
- Robba C.
- Battaglini D.
- De Maria A.
- Brunetti I.
- Patroniti N.
- Briano F.
- Bruzzone B.
- Guarona G.
- Magnasco L.
- Dentone C.
- Icardi G.
- Pelosi P.
- Luzzati R.
- Bassetti M.
- Others:
- Giacobbe, D. R.
- Di Bella, S.
- Dettori, S.
- Brucci, G.
- Zerbato, V.
- Pol, R.
- Segat, L.
- D'Agaro, P.
- Roman-Pognuz, E.
- Friso, F.
- Principe, L.
- Lucangelo, U.
- Ball, L.
- Robba, C.
- Battaglini, D.
- De Maria, A.
- Brunetti, I.
- Patroniti, N.
- Briano, F.
- Bruzzone, B.
- Guarona, G.
- Magnasco, L.
- Dentone, C.
- Icardi, G.
- Pelosi, P.
- Luzzati, R.
- Bassetti, M.
Description
Reactivation of herpes simplex virus type 1 (HSV-1) has been described in critically ill patients with coronavirus disease 2019 (COVID-19) pneumonia. In the present two-center retrospective experience, we primarily aimed to assess the cumulative risk of HSV-1 reactivation detected on bronchoalveolar fluid (BALF) samples in invasively ventilated COVID-19 patients with worsening respiratory function. The secondary objectives were the identification of predictors for HSV-1 reactivation and the assessment of its possible prognostic impact. Overall, 41 patients met the study inclusion criteria, and 12/41 patients developed HSV-1 reactivation (29%). No independent predictors of HSV-1 reactivation were identified in the present study. No association was found between HSV-1 reactivation and mortality. Eleven out of 12 patients with HSV-1 reactivation received antiviral therapy with intravenous acyclovir. In conclusion, HSV-1 reactivation is frequently detected in intubated patients with COVID-19. An antiviral treatment in COVID-19 patients with HSV-1 reactivation and worsening respiratory function might be considered.
Additional details
- URL
- http://hdl.handle.net/11567/1078139
- URN
- urn:oai:iris.unige.it:11567/1078139
- Origin repository
- UNIGE