Increased serum level of N-terminal Pro-B-type natriuretic peptide in psoriatic patients: a single-center study

Background: Psoriasis is associated with multiple comorbidities, including cardiovascular disease. Identifying biomarkers such as N-terminal fragment of the BNP precursor (NT-pro-BNP) with preventive, diagnostic, and prognostic implications in the cardiovascular diseases of psoriatic patients may be helpful in these patient's management. However, their predictive ability for future cardiovascular events in psoriatic patients is still unknown. Therefore, the study aimed to determine whether NT-pro-BNP levels were increased in psoriatic patients. Methods: One hundred forty psoriatic patients without cardiovascular disease and 140 healthy control patients were enrolled. Results: The NT-pro-BNP level was significantly correlated with lipid profile but not with disease duration; or the ongoing biologic therapy. Conclusions: Our work demonstrates that pro-BNP values are higher in patients with psoriasis than in controls and emphasizes the correlation between psoriasis and cardiovascular disease and the importance of biomarkers that can identify those patients most at risk of developing cardiovascular disease.