Published 2017
| Version v1
Publication
The Alzheimer's disease metabolic brain pattern in mild cognitive impairment
Description
We investigated the expression of the Alzheimer's disease-related metabolic brain pattern (ADRP) in (18)F-FDG-PET scans of 44 controls, 27 patients with mild cognitive impairment (MCI) who did not convert to Alzheimer's disease (AD) after five or more years of clinical follow-up, 95 MCI patients who did develop AD dementia on clinical follow-up, and 55 patients with mild-to-moderate AD. The ADRP showed good sensitivity (84%) and specificity (86%) for MCI-converters when compared to controls, but limited specificity when compared to MCI non-converters (66%). Assessment of (18)F-FDG-PET scans on a case-by-case basis using the ADRP may be useful for quantifying disease progression.
Additional details
Identifiers
- URL
- http://hdl.handle.net/11567/876139
- URN
- urn:oai:iris.unige.it:11567/876139
Origin repository
- Origin repository
- UNIGE