Published 2020
| Version v1
Publication
FOXA1 Mutations Reveal Distinct Chromatin Profiles and Influence Therapeutic Response in Breast Cancer
- Creators
- Arruabarrena-Aristorena A.
- Maag J. L. V.
- Kittane S.
- Cai Y.
- Karthaus W. R.
- Ladewig E.
- Park J.
- Kannan S.
- Ferrando L.
- Cocco E.
- Ho S. Y.
- Tan D. S.
- Sallaku M.
- Wu F.
- Acevedo B.
- Selenica P.
- Ross D. S.
- Witkin M.
- Sawyers C. L.
- Reis-Filho J. S.
- Verma C. S.
- Jauch R.
- Koche R.
- Baselga J.
- Razavi P.
- Toska E.
- Scaltriti M.
- Others:
- Arruabarrena-Aristorena, A.
- Maag, J. L. V.
- Kittane, S.
- Cai, Y.
- Karthaus, W. R.
- Ladewig, E.
- Park, J.
- Kannan, S.
- Ferrando, L.
- Cocco, E.
- Ho, S. Y.
- Tan, D. S.
- Sallaku, M.
- Wu, F.
- Acevedo, B.
- Selenica, P.
- Ross, D. S.
- Witkin, M.
- Sawyers, C. L.
- Reis-Filho, J. S.
- Verma, C. S.
- Jauch, R.
- Koche, R.
- Baselga, J.
- Razavi, P.
- Toska, E.
- Scaltriti, M.
Description
Arruabarrena-Aristorena et al. determine that mutations in the pioneer transcription factor FOXA1 lower the therapeutic response to aromatase inhibitors in ER+ breast cancer. Mechanistically, two phenotypic groups are established: hypermorphic Wing2 mutants that augment estrogen response, and a neomorphic SY242CS mutant that promotes an alternative pioneering, and cistromic and transcriptomic function.
Additional details
- URL
- https://hdl.handle.net/11567/1121316
- URN
- urn:oai:iris.unige.it:11567/1121316
- Origin repository
- UNIGE