Published March 2, 2020
| Version v1
Journal article
Design and synthesis of a peptide derivative of ametantrone targeting the major groove of the d(GGCGCC) 2 palindromic sequence
Contributors
Others:
- Università degli Studi di Brescia = University of Brescia (UniBs)
- Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques (LCBPT - UMR 8601) ; Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)
- Institut de Chimie de Nice (ICN) ; Université Nice Sophia Antipolis (1965 - 2019) (UNS) ; COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)
- Laboratoire de chimie théorique (LCT) ; Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)
- Department of Pharmaceutical and Pharmacological Sciences [Padova] ; Università degli Studi di Padova = University of Padua (Unipd)
Description
We report the synthesis of a peptide derivative of antitumor anthraquinones, designed to target GC-rich palindromic sequences. It has micromolar activities on three cancer cell lines and is fifty times less toxic than mitoxantrone on a healthy line.
Abstract
International audienceAdditional details
Identifiers
- URL
- https://hal-univ-paris.archives-ouvertes.fr/hal-03689989
- URN
- urn:oai:HAL:hal-03689989v1
Origin repository
- Origin repository
- UNICA