Smoking in Systemic Sclerosis: a Longitudinal European Scleroderma Trials and Research Group Study
- Creators
- Jaeger VK
- Valentini G
- Hachulla E
- Cozzi F
- Distler O
- Airó P
- Czirják L
- Allanore Y
- Siegert E
- Rosato E
- Matucci-Cerinic M
- Caimmi C
- Henes J
- Carreira PE
- Smith V
- Del Galdo F
- Denton CP
- Ullman S
- Langhe E
- Riccieri V
- Alegre-Sancho JJ
- Rednic S
- Müller-Ladner U
- Walker UA
- Lidia P. Ananieva
- Florenzo Iannone
- JeorgH. W. Distler
- Eduardo Kerzberg
- Bojana Stamenkovic
- José Antonio Pereira Da Silva
- Ivan Catellvì
- SuleYavuz
- Kamal Solanki
- Branimir Anic
- Esthela Loyo
- Tim Schmeiser
- Ruxandra Maria Ionescu
- Peter Villiger
- Francesco Paolo Cantatore
- Paloma Garcia de la Pena Lefebvre
- Carina Mihai
- Dominique Farge Bancel
- Pierluigi Meroni
- Thierry Martin
- Stefan Heitmann
- Nicolas Hunzelmann
- Fahrettin Oksel
- Washington Bianchi
- Sara Bongiovanni
- Radim Becvar
- Thierry Zenone
- Alexandra Balbir-Gurman
- Piotr Wiland
- Pawel Zebryk
- FrancßoisSpertini
- Lori Chung
- Alessandra Vacca
- Carlo Chizzolini
- Carlo Francesco Selmi
- Cristina-Mihaela Tanaseanu
- Ira Litinsky
- Frederic A. Houssiau
- Brigitte Krummel-Lorenz
- Vivien M. Hsu
- Francisca Fontes
- Alexandra Maria Burlui
- Duska Martinovic
- Sergei Popa
- Itzhak Rosner
- Carmel Mallia
- Rosario Foti
- Luc Mouthon
- Martin Aringer
- Jacob van Laar
- Roger Hesselstrand
- Maria Rosa Pozzi
- Gabriela Riemekasten
- Maurizio Cutolo
- Paul Hasler
- Zea Mendoza Antonio
- Cord Sunderkotter
- Codrina Ancuta
- Jean Sibilia
- Roberto Caporali
- Armando Gabrielli
- Raffaele Pellerito
- Ariane Herrick
- Øyvind Midtvedt
- Kilian Eyerich
- Brigitte Granel
- Lesley Ann Saketkoo
- Maura Couto
- Yael Eizikovits
- Giuseppina Abignano.
- Others:
- Vk, Jaeger
- G, Valentini
- E, Hachulla
- F, Cozzi
- O, Distler
- P, Airó
- L, Czirják
- Y, Allanore
- E, Siegert
- E, Rosato
- M, Matucci-Cerinic
- C, Caimmi
- J, Hene
- Pe, Carreira
- V, Smith
- F, Del Galdo
- Cp, Denton
- S, Ullman
- E, Langhe
- V, Riccieri
- Jj, Alegre-Sancho
- S, Rednic
- U, Müller-Ladner
- Ua, Walker
- Ananieva, Lidia P.
- Iannone, Florenzo
- Distler, JeorgH. W.
- Kerzberg, Eduardo
- Stamenkovic, Bojana
- Antonio Pereira Da Silva, José
- Catellvì, Ivan
- Suleyavuz,
- Solanki, Kamal
- Anic, Branimir
- Loyo, Esthela
- Schmeiser, Tim
- Maria Ionescu, Ruxandra
- Villiger, Peter
- Paolo Cantatore, Francesco
- Garcia de la Pena Lefebvre, Paloma
- Mihai, Carina
- Farge Bancel, Dominique
- Meroni, Pierluigi
- Martin, Thierry
- Heitmann, Stefan
- Hunzelmann, Nicola
- Oksel, Fahrettin
- Bianchi, Washington
- Bongiovanni, Sara
- Becvar, Radim
- Zenone, Thierry
- Balbir-Gurman, Alexandra
- Wiland, Piotr
- Zebryk, Pawel
- Francßoisspertini,
- Chung, Lori
- Vacca, Alessandra
- Chizzolini, Carlo
- Francesco Selmi, Carlo
- Tanaseanu, Cristina-Mihaela
- Litinsky, Ira
- Houssiau, Frederic A.
- Krummel-Lorenz, Brigitte
- Hsu, Vivien M.
- Fontes, Francisca
- Maria Burlui, Alexandra
- Martinovic, Duska
- Popa, Sergei
- Rosner, Itzhak
- Mallia, Carmel
- Foti, Rosario
- Mouthon, Luc
- Aringer, Martin
- van Laar, Jacob
- Hesselstrand, Roger
- Rosa Pozzi, Maria
- Riemekasten, Gabriela
- Cutolo, Maurizio
- Hasler, Paul
- Mendoza Antonio, Zea
- Sunderkotter, Cord
- Ancuta, Codrina
- Sibilia, Jean
- Caporali, Roberto
- Gabrielli, Armando
- Pellerito, Raffaele
- Herrick, Ariane
- Midtvedt, Øyvind
- Eyerich, Kilian
- Granel, Brigitte
- Ann Saketkoo, Lesley
- Couto, Maura
- Eizikovits, Yael
- Abignano., Giuseppina
Description
Objective: Data on the role of tobacco exposure in systemic sclerosis (SSc; scleroderma) severity and progression are scarce. We aimed to assess the effects of smoking on the evolution of pulmonary and skin manifestations, based on the European Scleroderma Trials and Research group database. Methods: Adult SSc patients with data on smoking history and a 12–24-month follow-up visit were included. Associations of severity and progression of organ involvement with smoking history and the Comprehensive Smoking Index were assessed using multivariable regression analyses. Results: A total of 3,319 patients were included (mean age 57 years, 85% female); 66% were never smokers, 23% were ex-smokers, and 11% were current smokers. Current smokers had a lower percentage of antitopoisomerase autoantibodies than previous or never smokers (31% versus 40% and 45%, respectively). Never smokers had a higher baseline forced expiratory volume in 1 second/forced vital capacity (FEV1/FVC) ratio than previous and current smokers (P < 0.001). The FEV1/FVC ratio declined faster in current smokers than in never smokers (P = 0.05) or ex-smokers (P = 0.01). The baseline modified Rodnan skin thickness score (MRSS) and the MRSS decline were comparable across smoking groups. Although heavy smoking (>25 pack-years) increased the odds of digital ulcers by almost 50%, there was no robust adverse association of smoking with digital ulcer development. Conclusion: The known adverse effect of smoking on bronchial airways and alveoli is also observed in SSc patients; however, robust adverse effects of smoking on the progression of SSc-specific pulmonary or cutaneous manifestations were not observed. © 2018, American College of Rheumatology
Additional details
- URL
- http://hdl.handle.net/11567/914883
- URN
- urn:oai:iris.unige.it:11567/914883
- Origin repository
- UNIGE