Associations among education, age, and the dementia with Lewy bodies (DLB) metabolic pattern: A European-DLB consortium project
- Creators
- Bauckneht M.
- Chincarini A.
- Brendel M.
- Rominger A.
- Beyer L.
- Bruffaerts R.
- Vandenberghe R.
- Kramberger M. G.
- Trost M.
- Garibotto V.
- Nicastro N.
- Frisoni G. B.
- Lemstra A. W.
- van Berckel B. N. M.
- Pilotto A.
- Padovani A.
- Ochoa-Figueroa M. A.
- Davidsson A.
- Camacho V.
- Peira E.
- Arnaldi D.
- Pardini M.
- Donegani M. I.
- Raffa S.
- Miceli A.
- Sambuceti G.
- Aarsland D.
- Nobili F.
- Morbelli S.
- Others:
- Bauckneht, M.
- Chincarini, A.
- Brendel, M.
- Rominger, A.
- Beyer, L.
- Bruffaerts, R.
- Vandenberghe, R.
- Kramberger, M. G.
- Trost, M.
- Garibotto, V.
- Nicastro, N.
- Frisoni, G. B.
- Lemstra, A. W.
- van Berckel, B. N. M.
- Pilotto, A.
- Padovani, A.
- Ochoa-Figueroa, M. A.
- Davidsson, A.
- Camacho, V.
- Peira, E.
- Arnaldi, D.
- Pardini, M.
- Donegani, M. I.
- Raffa, S.
- Miceli, A.
- Sambuceti, G.
- Aarsland, D.
- Nobili, F.
- Morbelli, S.
Description
Introduction: We assessed the influence of education as a proxy of cognitive reserve and age on the dementia with Lewy bodies (DLB) metabolic pattern. Methods: Brain 18F-fluorodeoxyglucose positron emission tomography and clinical/demographic information were available in 169 probable DLB patients included in the European DLB-consortium database. Principal component analysis identified brain regions relevant to local data variance. A linear regression model was applied to generate age- and education-sensitive maps corrected for Mini-Mental State Examination score, sex (and either education or age). Results: Age negatively covaried with metabolism in bilateral middle and superior frontal cortex, anterior and posterior cingulate, reducing the expression of the DLB-typical cingulate island sign (CIS). Education negatively covaried with metabolism in the left inferior parietal cortex and precuneus (making the CIS more prominent). Discussion: These findings point out the importance of tailoring interpretation of DLB biomarkers considering the concomitant effect of individual, non–disease-related variables such as age and cognitive reserve.
Additional details
- URL
- http://hdl.handle.net/11567/1044690
- URN
- urn:oai:iris.unige.it:11567/1044690
- Origin repository
- UNIGE