Double asymmetric hydrogenation of conjugated dienes: a self-breeding chirality route for C2 symmetric 1,4-diols

Description

The synthesis and double asymmetric hydrogenation of (Z,Z)-1,3- diene-1,4-diyl diacetates is described. In this reaction C2/meso ratios up to 85 : 15 and enantioselectivities up to 97% ee have been achieved. As the hydrogenation products can be converted into chiral 1,4-diols, key starting materials for the preparation of the best catalysts used, this catalytic system enables a self-breeding chirality process

Abstract

Ministerio de Economía y Competitividad español (MINECO)-CTQ2016-75193-P

Abstract

Agencia Estatal de Investigación española (AEI) y Fondos FEDER de la Unión Europea-CTQ2016-75986-P y CTQ2016-81797- REDC

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