Speed matters: How subtle changes in DNA end resection rate affect repair

Description

The contribution of BRCA1 (breast cancer 1) to the repair of broken DNA is well established, but its real role at the molecular level is less well understood. By developing a new high-resolution, single-molecule technique, we have now shown that BRCA1 accelerates the processing of DNA breaks that subsequently engage in homologous recombination.

Abstract

España, Ministerio de Economía y Competitividad, SAF2010-14877

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