A new mouse model for c-Myc induced choroid plexus carcinoma

Creators: El Nagar, Salsabiel; Lamonerie, Thomas; Billon, Nathalie

Other:: Institut de Biologie Valrose (IBV) ; Université Nice Sophia Antipolis (1965 - 2019) (UNS) ; COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)

Description

C horoid plexus carcinomas (CPCs) are World Health Organization [WHO] grade III brain tumors predominantly found in children (1,2). Implementation of successful therapy for CPCs has been hampered by the lack of appropriate preclinical models. Here we review the Otx2 CreER/ +; Rosa MycT58A/MycT58A ; Trp 53fl/fl novel CPC mouse model we recently generated, and compare it to existing models.

Abstract

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A new mouse model for c-Myc induced choroid plexus carcinoma

Description

Abstract

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