Identification of the Salmonella enterica damX gene product, an inner membrane protein involved in bile resistance

Description

The damX gene product of Salmonella enterica serovar Typhimurium is a protein located in the inner membrane. DamX migrates as a 70-kDa protein in SDS-PAGE even though the predicted protein size is 46 kDa. Synthesis of DamX protein occurs in both exponential- and stationary-phase cultures. Disruption of damX causes severe sensitivity to bile. Lack of the outer membrane protein AsmA suppresses bile sensitivity in Salmonella damX mutants.

Abstract

Ministerio de Ciencia e Innovación y European Regional Fund BIO2007-67457-CO2 CSD2008-00013

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