Deciphering the quality of SARS-CoV-2 specific T-cell response associated with disease severity, immune memory and heterologous response
- Others:
- Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología
- Instituto de Salud Carlos III
- European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER)
- Consejería de Salud, Junta de Andalucía
- Consejeria de Transformacion Economica, Industria, Conocimiento y Universidades, Junta de Andalucia
Description
SARS-CoV-2 specific T-cell response has been associated with disease severity, immune memory and heterologous response to endemic coronaviruses. However, an integrative approach combining a comprehensive analysis of the quality of SARS-CoV-2 specific T-cell response with antibody levels in these three scenarios is needed. In the present study, we found that, in acute infection, while mild disease was associated with high T-cell polyfunctionality biased to IL-2 production and inversely correlated with anti-S IgG levels, combinations only including IFN-γ with the absence of perforin production predominated in severe disease. Seven months after infection, both non-hospitalised and previously hospitalised patients presented robust anti-S IgG levels and SARS-CoV-2 specific T-cell response. In addition, only previously hospitalised patients showed a T-cell exhaustion profile. Finally, combinations including IL-2 in response to S protein of endemic coronaviruses were the ones associated with SARS-CoV-2 S-specific T-cell response in pre-COVID-19 healthy donors' samples. These results could have implications for protective immunity against SARS-CoV-2 and recurrent COVID-19 and may help for the design of new prototypes and boosting vaccine strategies.
Additional details
- URL
- https://idus.us.es/handle//11441/138485
- URN
- urn:oai:idus.us.es:11441/138485
- Origin repository
- USE