Published September 23, 2024
| Version v1
Publication
Coupling Between Messenger RNA Synthesis and Degradation during Genome Expression
Description
Genome expression involves the synthesis of messenger RNA (mRNA), a short lived molecule whose translation directs the synthesis of cellular proteins and that is
subject to degradation after the translation process. Up to the date, mRNA synthesis
and degradation has been considered as a linear phenomenon in which the above
steps occur subsequently without a regulatory interconnection. However, gene
expression can be studied as a global system in which all their stages are coupled
and interconnected by regulatory mechanisms. We have contributed to demonstrate
that the machineries of mRNA synthesis and degradation physically and functionally
interact in the cell nucleus. We have proposed that it allows the cross-regulation of
transcription with mRNA degradation and vice versa, giving rise to a circular system,
which would explain the large robustness observed in gene expression (Haimovich et
al, 2013).
Additional details
Identifiers
- URL
- https://idus.us.es/handle//11441/162734
- URN
- urn:oai:idus.us.es:11441/162734