Management and outcomes of adolescent and young adult sarcoma patients: results from the French nationwide database NETSARC.
- Creators
- Kubicek, P.
- Cesne, A. L.
- Lervat, C.
- Toulmonde, M.
- Chevreau, C.
- Duffaud, F.
- Le Nail, L. R.
- Morelle, M.
- Gaspar, N.
- Vérité, C.
- Castex, M. P.
- Penel, Nicolas
- Saada, E.
- Causeret, S.
- Bertucci, F.
- Perrin, C.
- Bompas, E.
- Orbach, D.
- Laurence, V.
- Piperno-Neumann, S.
- Anract, P.
- Rios, M.
- Gentet, J. C.
- Mascard, É.
- Pannier, S.
- Blouin, P.
- Carrère, S.
- Chaigneau, L.
- Soibinet-Oudot, P.
- Corradini, N.
- Boudou-Rouquette, P.
- Ruzic, J. C.
- Lebrun-Ly, V.
- Dubray-Longeras, P.
- Varatharajah, S.
- Lebbe, C.
- Ropars, M.
- Kurtz, J. E.
- Guillemet, C.
- Lotz, J. P.
- Berchoud, J.
- Cherrier, G.
- Ducimetière, F.
- Chemin, C.
- Italiano, A.
- Honoré, C.
- Desandes, E.
- Blay, J. Y.
- Gouin, F.
- Marec-Bérard, P.
- Others:
- Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO) ; UNICANCER
- Institut Gustave Roussy (IGR)
- Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)
- Institut Bergonié [Bordeaux] ; UNICANCER
- Institut Claudius Regaud
- Hôpital de la Timone [CHU - APHM] (TIMONE)
- CHU Trousseau [Tours] ; Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)
- Centre Léon Bérard [Lyon]
- CHU Bordeaux [Bordeaux]
- Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)
- Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS) ; Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)
- Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] (UNICANCER/CAL) ; UNICANCER-Université Côte d'Azur (UCA)
- Service de chirurgie [Centre Georges-François Leclerc] ; Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] (UNICANCER/CRLCC-CGFL) ; UNICANCER-UNICANCER
- Institut Paoli-Calmettes (IPC) ; Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)
- CRLCC Eugène Marquis (CRLCC)
- Institut Curie [Paris]
- Hôpital Cochin [AP-HP] ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)
- Institut de Cancérologie de Lorraine - Alexis Vautrin [Nancy] (UNICANCER/ICL) ; UNICANCER
- Institut Necker Enfants-Malades (INEM - UM 111 (UMR 8253 / U1151)) ; Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)
- CHU Necker - Enfants Malades [AP-HP] ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)
- Institut du Cancer de Montpellier (ICM)
- Service d'Oncologie Médicale [CHRU Besançon] ; Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Franche-Comté (UFC) ; Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)
- Institut Jean Godinot [Reims] ; UNICANCER
- Institut d'hématologie et d'oncologie pédiatrique [CHU - HCL] (IHOPe) ; Hospices Civils de Lyon (HCL)
- Centre Hospitalier de Mayotte
- Hôpital Dupuytren [CHU Limoges]
- Centre Jean Perrin [Clermont-Ferrand] (UNICANCER/CJP) ; UNICANCER
- Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC) ; Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)
- Hopital Saint-Louis [AP-HP] (AP-HP) ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)
- Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital
- Institut de Cancérologie de Strasbourg Europe (ICANS)
- Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen (CLCC Henri Becquerel)
- CHU Tenon [AP-HP] ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)
- Centre hospitalier universitaire de Nantes (CHU Nantes)
- Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)) ; Conservatoire National des Arts et Métiers [CNAM] (CNAM) ; HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (INRAE)
Description
BackgroundThe initial management of patients with sarcoma is a critical issue. We used the nationwide French National Cancer Institute-funded prospective sarcoma database NETSARC to report the management and oncologic outcomes in adolescents and young adults (AYAs) patients with sarcoma at the national level.Patients and methodsNETSARC database gathers regularly monitored and updated data from patients with sarcoma. NETSARC was queried for patients (15–30 years) with sarcoma diagnosed from 2010 to 2017 for whom tumor resection had been performed. We reported management, locoregional recurrence-free survival (LRFS), progression-free survival (PFS), and overall survival (OS) in AYA treated in French reference sarcoma centers (RSC) and outside RSC (non-RSC) and conducted multivariable survival analyses adjusted for classical prognostic factors.ResultsAmong 3,227 patients aged 15–30 years with sarcoma diagnosed between 2010 and 2017, the study included 2,227 patients with surgery data available, among whom 1,290 AYAs had been operated in RSC, and 937 AYAs in non-RSC. Significant differences in compliance to guidelines were observed including pre-treatment biopsy (RSC: 85.9%; non-RSC 48.1%), pre-treatment imaging (RSC: 86.8%; non-RSC: 56.5%) and R0 margins (RSC 57.6%; non-RSC: 20.2%) (p < 0.001). 3y-OS rates were 81.1% (95%CI 78.3–83.6) in AYA in RSC and 82.7% (95%CI 79.4–85.5) in AYA in non-RSC, respectively. Whereas no significant differences in OS was observed in AYAs treated in RSC and in non-RSC, LRFS and PFS were improved in AYAs treated in RSC compared to AYAs treated in non-RSC (Hazard Ratios (HR): 0.58 and 0.83, respectively).ConclusionsThis study highlights the importance for AYA patients with sarcoma to be managed in national sarcoma reference centers involving multidisciplinary medical teams with paediatric and adult oncologists.
Abstract
International audience
Additional details
- URL
- https://hal.univ-lille.fr/hal-04315885
- URN
- urn:oai:HAL:hal-04315885v1
- Origin repository
- UNICA