Population pharmacokinetics of colistin: implications for clinical use for Gram-negative pathogens

Creators: Pachón Ibáñez, María Eugenia; Docobo Pérez, Fernando; Blanquero Bravo, Rafael; Garnacho Montero, José; Benítez Peña, Sandra; Dimopoulos, George; Rosso Fernández, Clara; Gutiérrez Pizarraya, Antonio; López Cortés, Luis Fernando; Cisneros Herreros, José Miguel

Others:: Universidad de Sevilla. Departamento de Estadística e Investigación Operativa; Universidad de Sevilla. FQM329: Optimización; Universidad de Sevilla. CTS210: Adherencia Bacteriana a Nuevos Biomateriales

Description

The objective of this study was to characterize the pharmacokinetics of colistin methanesulphonate (CMS) and colistin in critically ill patients following the administration of a 4.5 MU CMS loading dose follow by 3MU CMS Q8. A population PK model and Monte Carlo simulation were used to calculate the probability of target attainment (PTA) against Acinetobacter baumannii and Pseudomonas aeruginosa by considering a range of MIC values seen in the clinic.

Population pharmacokinetics of colistin: implications for clinical use for Gram-negative pathogens

Description

Additional details