Published August 31, 2017
| Version v1
Publication
Orientation of the central domains of KSRP and its implications for the interaction with the RNA targets
Description
KSRP is a multi-domain RNA-binding protein that recruits the exosome-containing mRNA degradation complex to mRNAs coding for cellular proliferation and inflammatory response factors. The selectivity of this mRNA degradation mechanism relies on KSRP recognition of AU-rich elements in the mRNA 3′UTR, that is mediated by KSRP's KH domains. Our structural analysis shows that the inter-domain linker orients the two central KH domains of KSRP—and their RNA-binding surfaces—creating a two-domain unit. We also show that this inter-domain arrangement is important to the interaction with KSRP's RNA targets.
Additional details
- URL
- https://idus.us.es/handle/11441/64106
- URN
- urn:oai:idus.us.es:11441/64106
- Origin repository
- USE