3,5-Diphenyl-1H-pyrazole derivatives. XII. N-substituted 4-amino-1-(2-hydroxy- or 2-alkylaminoethyl)-3,5-diphenyl-1H-pyrazoles with local anesthetic, analgesic and platelet antiaggregating activities.

Description

The synthesis of 4-amino-3,5-diphenyl-1H-pyrazole-1-ethanol, as well as of its N-Me, N-Et and N,N-di-Me derivs. is described. A series of 1-(2-alkylaminoethyl)-3,5-diphenyl-1H-pyrazole-4-amines and of N-substituted 4-dimethylamino-3,5-diphenyl-1H-pyrazole-1-ethanamines were also prepd. Some of the above compds. showed marked local anesthetic and analgesic activities in rats and mice and marked in vitro platelet antiaggregating activities, as well as moderate antiinflammatory and antipyretic activities in rats and mice.

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