Fisher-KPP with time dependent diffusion is able to model cell-sheet activated and inhibited wound closure
- Others:
- Laboratoire de Modélisation Mathématique et Numérique dans les Sciences de l'Ingénieur [Tunis] (LR-LAMSIN-ENIT) ; Ecole Nationale d'Ingénieurs de Tunis (ENIT) ; Université de Tunis El Manar (UTM)-Université de Tunis El Manar (UTM)
- Ecole Supérieure des Sciences et de Technologie de Hammam Sousse (ESSTHS)
- Analysis and Control of Unsteady Models for Engineering Sciences (ACUMES) ; Inria Sophia Antipolis - Méditerranée (CRISAM) ; Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)
- Laboratoire Jean Alexandre Dieudonné (JAD) ; Université Nice Sophia Antipolis (1965 - 2019) (UNS) ; COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)
Description
The popular 2D Fisher-KPP equation with constant parameters fails to predict activated or inhibited cell-sheet wound closure. Here, we consider the case where the collective diffusion coefficient is time dependent, with a 3-parameter sigmoid profile. The sigmoid is taken S-shaped for the activated assays, and Z-shaped for the inhibited ones. For two activated and two inhibited assays, our model is able to predict with a very good accuracy features of the wound closure like as the time evolution of the wound area and migration rate. The calibrated parameters are consistent with respect to different subsets of the experimental datasets used for the calibration. However, the assumption of sigmoid time profile for the proliferation rate yields calibrated parameters critically dependent on the dataset used for calibration.
Abstract
International audience
Additional details
- URL
- https://hal.inria.fr/hal-01575717
- URN
- urn:oai:HAL:hal-01575717v1
- Origin repository
- UNICA