Published September 28, 2017 | Version v1
Publication Metadata-only

Intracellular penetration and activity of gemifloxacin in human polymorphonuclear leukocytes

García Luque, Isabel
Pascual Hernández, Álvaro
Joyanes, Providencia
Perea Pérez, Evelio José
Other:
Universidad de Sevilla. Departamento de Microbiología

Description

The intracellular penetration and activity of gemifloxacin in human polymorphonuclear leukocytes (PMN) were evaluated. Gemifloxacin reached intracellular concentrations eight times higher than extracellular concentrations. The uptake was rapid, reversible, and nonsaturable and was affected by environmental temperature, cell viability, and membrane stimuli. At therapeutic extracellular concentrations, gemifloxacin showed intracellular activity against Staphylococcus aureus.

Additional details

Identifiers Origin repository
Created:
March 27, 2023
Modified:
November 28, 2023