Published 2011
| Version v1
Publication
Seizures can precede cognitive symptoms in late-onset Alzheimer's disease.
Description
This study describes late-onset Alzheimer's disease (LOAD) in the mild cognitive impairment (MCI) stage, debuting with seizures in a 72 year-old woman. Prodromal AD was consistently diagnosed with four among amyloidosis and neurodegeneration biomarkers about 1 year after onset of seizures. Genetic assessment demonstrated apolipoprotein E ε2/ε3 genotype and three intronic single nucleotide substitutions, two in presenilin 1 and one in amyloid-β protein precursor genes. This case of seizures at onset of LOAD with severe signs of brain amyloidosis and neurodegeneration but with just MCI leads to a re-appraisal of the intriguing relationship between AD pathology and neuron excitability in humans.
Additional details
Identifiers
- URL
- http://hdl.handle.net/11567/491120
- URN
- urn:oai:iris.unige.it:11567/491120
Origin repository
- Origin repository
- UNIGE