Published May 27, 2024
| Version v1
Journal article
Sex‐specific impact of psychosocial stress on hematopoiesis and blood leukocytes
Contributors
Others:
- Centre méditerranéen de médecine moléculaire (C3M) ; Université Nice Sophia Antipolis (1965 - 2019) (UNS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UniCA)
- Laboratoire de PhysioMédecine Moléculaire (LP2M) ; Université Nice Sophia Antipolis (1965 - 2019) (UNS)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UniCA)
- Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U 1011 (RNMCD) ; Institut Pasteur de Lille ; Pasteur Network (Réseau International des Instituts Pasteur)-Pasteur Network (Réseau International des Instituts Pasteur)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [CHU Lille] (CHRU Lille)
- Institut Pasteur de Lille ; Pasteur Network (Réseau International des Instituts Pasteur)
- Centre Hospitalier Régional Universitaire [CHU Lille] (CHRU Lille)
Description
Abstract Stress exposure has been shown to modulate innate and adaptive immune responses. Indeed, stress favors myelopoiesis and monocyte generation and contributes to cardiovascular disease development. As sex hormones regulate innate and adaptive immune responses, we decided to investigate whether stress exposure leads to a different immune response in female and male mice. Our data demonstrated that psychosocial stressinduced neutrophilia in male, but not female mice. Importantly, we identified that B‐cell numbers were reduced in female, but not male mice upon exposure to stress. Thus, our study revealed that the stress‐induced immune alterations are sex‐dependent, and this is an important feature to consider for future investigations.
Abstract
International audienceAdditional details
Identifiers
- URL
- https://inserm.hal.science/inserm-04750207
- URN
- urn:oai:HAL:inserm-04750207v1
Origin repository
- Origin repository
- UNICA