Published November 18, 2016 | Version v1
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Exploring architectures displaying multimeric presentations of a trihydroxypiperidine iminosugar

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The synthesis of new multivalent architectures based on a trihydroxypiperidine α -fucosidase inhibitor is reported herein. Tetrava- lent and nonavalent dendrimers were obtained by means of the click chemistry approach involving the copper azide-alkyne- catalyzed cycloaddition (CuAAC) between suitable scaffolds bearing terminal alkyne moieties and an azido-functionalized piperi- dine as the bioactive moiety. A preliminary biological investigation is also reported towards commercially available and human glycosidases

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URL
https://idus.us.es/handle/11441/48868
URN
urn:oai:idus.us.es:11441/48868

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