Eryloside W, a triterpenoid saponin from the sponge Dictyonella marsilii

Creators: Genta-Jouve, Grégory; Boughanem, Cecile; Ocana, Oscar; Perez, Thierry; Thomas, Olivier P.

Others:: Equipe Pharmacognosie (UMR 8638) ; Chimie Organique, Médicinale et Extractive et Toxicologie Expérimentale (COMETE - UMR 8638) ; Université Paris Descartes - Paris 5 (UPD5)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS); Institut méditerranéen de biodiversité et d'écologie marine et continentale (IMBE) ; Avignon Université (AU)-Aix Marseille Université (AMU)-Institut de recherche pour le développement [IRD] : UMR237-Centre National de la Recherche Scientifique (CNRS); Institut de Chimie de Nice (ICN) ; Université Nice Sophia Antipolis (1965 - 2019) (UNS) ; COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)

Description

A new saponin derivative named eryloside W was isolated from the marine sponge Dictyonella marsilii (Demospongiae, Halichondrida, Dictyonellidae). The structure of the compound was elucidated through extensive use of 1D and 2D nuclear magnetic resonance and mass spectrometry. Determination of the absolute configuration was performed using electronic circular dichroism (ECD) by comparison of experimental and time dependent density functional theory (TDDFT) calculated spectra. This is the first occurrence of a saponin derivative produced by a marine sponge present in the Mediterranean. (C) 2015 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

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Eryloside W, a triterpenoid saponin from the sponge Dictyonella marsilii

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