Published 2017
| Version v1
Publication
Prognostic factors in ectopic Cushing's syndrome due to neuroendocrine tumors: a multicenter study
Creators
- Davi', Maria Vittoria
- Cosaro, Elisa
- Piacentini, Serena
- Reimondo, Giuseppe
- Albiger, Nora
- Arnaldi, Giorgio
- Faggiano, Antongiulio
- Mantovani, Giovanna
- Fazio, Nicola
- Piovesan, Alessandro
- Arvat, Emanuela
- Grimaldi, Franco
- Canu, Letizia
- Mannelli, Massimo
- Ambrogio, Alberto Giacinto
- Pecori Giraldi, Francesca
- Martini, Chiara
- Lania, Andrea
- Albertelli, Manuela
- Ferone, Diego
- Zatelli, Maria Chiara
- Campana, Davide
- Colao, Annamaria
- Scaroni, Carla
- Terzolo, Massimo
- De Marinis, Laura
- Cingarlini, Sara
- Micciolo, Rocco
- Francia, Giuseppe
Contributors
Others:
- Davi', Maria Vittoria
- Cosaro, Elisa
- Piacentini, Serena
- Reimondo, Giuseppe
- Albiger, Nora
- Arnaldi, Giorgio
- Faggiano, Antongiulio
- Mantovani, Giovanna
- Fazio, Nicola
- Piovesan, Alessandro
- Arvat, Emanuela
- Grimaldi, Franco
- Canu, Letizia
- Mannelli, Massimo
- Ambrogio, Alberto Giacinto
- Pecori Giraldi, Francesca
- Martini, Chiara
- Lania, Andrea
- Albertelli, Manuela
- Ferone, Diego
- Zatelli, Maria Chiara
- Campana, Davide
- Colao, Annamaria
- Scaroni, Carla
- Terzolo, Massimo
- De Marinis, Laura
- Cingarlini, Sara
- Micciolo, Rocco
- Francia, Giuseppe
Description
OBJECTIVE: Evidence is limited regarding outcome of patients with ectopic Cushing's syndrome (ECS) due to neuroendocrine tumors (NETs).DESIGN: We assessed the prognostic factors affecting the survival of patients with NETs and ECS.METHODS: Retrospective analysis of clinicopathological features, severity of hormonal syndrome, treatments from a large cohort of patients with NETs and ECS collected from 17 Italian centers.RESULTS: Our series included 110 patients, 58.2% female, with mean (±s.d.) age at diagnosis of 49.5 ± 15.9 years. The main sources of ectopic ACTH were bronchial carcinoids (BC) (40.9%), occult tumors (22.7%) and pancreatic (p)NETs (15.5%). Curative surgery was performed in 56.7% (70.2% of BC, 11% of pNETs). Overall survival was significantly higher in BC compared with pNETs and occult tumors (P = 0.033) and in G1-NETs compared with G2 and G3 (P = 0.007). Negative predictive factors for survival were severity of hypercortisolism (P
Additional details
Identifiers
- URL
- http://hdl.handle.net/11567/892338
- URN
- urn:oai:iris.unige.it:11567/892338
Origin repository
- Origin repository
- UNIGE