Performance of existing definitions and tests for the diagnosis of invasive aspergillosis in critically ill, adult patients: A systematic review with qualitative evidence synthesis
- Creators
- Bassetti M.
- Giacobbe D. R.
- Grecchi C.
- Rebuffi C.
- Zuccaro V.
- Scudeller L.
- Akova M.
- Alastruey-Izquierdo A.
- Arikan-Akdagli S.
- Azoulay E.
- Blot S.
- Cornely O. A.
- Lass-Florl C.
- Koehler P.
- Cuenca-Estrella M.
- de Lange D. W.
- De Rosa F. G.
- De Waele J. J.
- Dimopoulos G.
- Garnacho-Montero J.
- Hoenigl M.
- Kanj S. S.
- Lamoth F.
- Maertens J.
- Martin-Loeches I.
- Munoz P.
- Kullberg B. J.
- Agvald-Ohman C.
- Poulakou G.
- Rello J.
- Righi E.
- Sanguinetti M.
- Taccone F. S.
- Timsit J. -F.
- Torres A.
- Vazquez J. A.
- Wauters J.
- Calandra T.
- Asperges E.
- Tejada S.
- Lebihan C.
- Karaiskos I.
- Peghin M.
- Mortensen K. L.
- Vena A.
- Cortegiani A.
- Mercier T.
- Others:
- Bassetti, M.
- Giacobbe, D. R.
- Grecchi, C.
- Rebuffi, C.
- Zuccaro, V.
- Scudeller, L.
- Akova, M.
- Alastruey-Izquierdo, A.
- Arikan-Akdagli, S.
- Azoulay, E.
- Blot, S.
- Cornely, O. A.
- Lass-Florl, C.
- Koehler, P.
- Cuenca-Estrella, M.
- de Lange, D. W.
- De Rosa, F. G.
- De Waele, J. J.
- Dimopoulos, G.
- Garnacho-Montero, J.
- Hoenigl, M.
- Kanj, S. S.
- Lamoth, F.
- Maertens, J.
- Martin-Loeches, I.
- Munoz, P.
- Kullberg, B. J.
- Agvald-Ohman, C.
- Poulakou, G.
- Rello, J.
- Righi, E.
- Sanguinetti, M.
- Taccone, F. S.
- Timsit, J. -F.
- Torres, A.
- Vazquez, J. A.
- Wauters, J.
- Calandra, T.
- Asperges, E.
- Tejada, S.
- Lebihan, C.
- Karaiskos, I.
- Peghin, M.
- Mortensen, K. L.
- Vena, A.
- Cortegiani, A.
- Mercier, T.
Description
Objectives: To summarize the available evidence on the diagnostic performance for invasive aspergillosis (IA) in non-hematological, non-solid organ transplantation critically ill patients of the following: (i) existing definitions of IA (developed either for classical immunocompromised populations or for non-immunocompromised critically ill patients); (ii) laboratory tests; (iii) radiology tests. Methods: A systematic review was performed by evaluating studies assessing the diagnostic performance for IA of a definition/s and/or laboratory/radiology test/s vs. a reference standard (histology) or a reference definition. Results: Sufficient data for evaluating the performance of existing definitions and laboratory tests for the diagnosis of IA in critically ill patients is available only for invasive pulmonary aspergillosis. Against histology/autopsy as reference, the AspICU definition showed a promising diagnostic performance but based on small samples and applicable only to patients with positive respiratory cultures. Studies on laboratory tests consistently indicated a better diagnostic performance of bronchoalveolar lavage fluid (BALF) galactomannan (GM) than serum GM, and a suboptimal specificity of BALF and serum (1,3)-β-D-glucan. Conclusions: Evidence stemming from this systematic review will guide the discussion for defining invasive aspergillosis within the FUNDICU project. The project aims to develop a standard set of definitions for invasive fungal diseases in critically ill, adult patients.
Additional details
- URL
- http://hdl.handle.net/11567/1073431
- URN
- urn:oai:iris.unige.it:11567/1073431
- Origin repository
- UNIGE