Improved Vascular Transport Function Characterization in DSC-MRI via Deconvolution with Dispersion-Compliant Bases

Bolus dispersion affects the residue function computed via deconvolution of DSC-MRI data. The obtained effective residue function can be expressed as the convolution of the true one with a Vascular Transport Function (VTF) that characterizes dispersion. The state-of-the-art technique CPI+VTF allows to estimate the actual residue function by assuming a model of VTF. We propose to perform deconvolution representing the effective residue function with Dispersion-Compliant Bases (DCB) with no assumptions on the VTF, and then apply the CPI+VTF on DCB results, to improve performance.