Type 1 FSHD with 6–10 Repeated Units: Factors Underlying Severity in Index Cases and Disease Penetrance in Their Relatives Attention
- Creators
- Salort-Campana, Emmanuelle
- Fatehi, Farzad
- Beloribi-Djefaflia, Sadia
- Roche, Stéphane
- Nguyen, Karine
- Bernard, Rafaelle
- Cintas, Pascal
- Sole, Guilhem
- Bouhour, Françoise
- Ollagnon, Elisabeth
- Sacconi, Sabrina
- Echaniz-Laguna, Andoni
- Kuntzer, Thierry
- Lévy, Nicolas
- Magdinier, Frédérique
- Attarian, Shahram
- Others:
- Centre de référence des maladies neuromusculaires et de la SLA ; Hôpital de la Timone [CHU - APHM] (TIMONE)
- Marseille medical genetics - Centre de génétique médicale de Marseille (MMG) ; Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)
- Tehran University of Medical Sciences (TUMS)
- Département de génétique médicale [Hôpital de la Timone - APHM] ; Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE)-Institut National de la Santé et de la Recherche Médicale (INSERM)
- Centre Sclérose Latérale Amyotrophique et maladies, Unité de neurophysiologie clinique [CHU Toulouse] ; CHU Toulouse [Toulouse]
- Service de neurologie [Bordeaux] ; CHU Bordeaux [Bordeaux]-Groupe hospitalier Pellegrin
- Hôpital neurologique ; Hospices Civils de Lyon (HCL)
- Hôpital de la Croix-Rousse [CHU - HCL] ; Hospices Civils de Lyon (HCL)
- Institut de Biologie Valrose (IBV) ; Université Nice Sophia Antipolis (1965 - 2019) (UNS) ; COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)
- Fédération de Médecine Translationnelle de Strasbourg (FMTS) ; Université de Strasbourg (UNISTRA)
- Centre Hospitalier Universitaire Vaudois [Lausanne] (CHUV)
Description
Molecular defects in type 1 facioscapulohumeral muscular dystrophy (FSHD) are caused by a heterozygous contraction of the D4Z4 repeat array from 1 to 10 repeat units (RUs) on 4q35. This study compared (1) the phenotype and severity of FSHD1 between patients carrying 6-8 vs. 9-10 RUs, (2) the amount of methylation in different D4Z4 regions between patients with FSHD1 with different clinical severity scores (CSS). This cross-sectional multicenter study was conducted to measure functional scales and for genetic analysis. Patients were classified into two categories according to RUs: Group 1, 6-8; Group 2, 9-10. Methylation analysis was performed in 27 patients. A total of 99 carriers of a contracted D4Z4 array were examined. No significant correlations between RUs and CSS (r = 0.04, p = 0.73) and any of the clinical outcome scales were observed between the two groups. Hypomethylation was significantly more pronounced in patients with high CSS (>3.5) than those with low CSS (<1.5) (in DR1 and 5P), indicating that the extent of hypomethylation might modulate disease severity. In Group 1, the disease severity is not strongly correlated with the allele size and is mostly correlated with the methylation of D4Z4 regions.
Abstract
International audience
Additional details
- URL
- https://hal.archives-ouvertes.fr/hal-02533845
- URN
- urn:oai:HAL:hal-02533845v1
- Origin repository
- UNICA