Where to from Here for Exercise-Induced Bronchoconstriction

Creators: Hallstrand, Teal S; Kippelen, Pascale; Larsson, Johan; Bougault, Valérie; van Leeuwen, Janneke; Driessen, Jean; Brannan, John

Others:: Division of Pulmonary and Critical Care, Department of Medicine, University of Washington; Centre for Sports Medicine and Human Performance, Brunel University; Lung and Allergy research division of respiratory medicine and allergy, Department of medicine, Karolinska Institutet, Karolinska University Hospital; Laboratoire Motricité Humaine Expertise Sport Santé (LAMHESS) ; Université Nice Sophia Antipolis (1965 - 2019) (UNS) ; COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université de Toulon (UTLN)-Université Côte d'Azur (UCA); department of pediatrics, Medisch Spectrum Twente, Enschede; Department of sports medicine, Tjongerschans Hospital, Heerenveen; Department of sleep and respiratory medicine, Westmead hospital, University of Sidney,

Description

The role of epithelial injury is an unanswered question in those with established asthma and in elite athletes who develop features of asthma and exercise-induced bronchorestriction (EIB) after years of training. The movement of water in response to changes in osmolarity is likely to be an important signal to the epithelium that may be central to the onset of EIB. It is generally accepted that the mast cell and its mediators play a major role in EIB and the presence of eosinophils is likely to enhance EIB severity.

Abstract

International audience

Where to from Here for Exercise-Induced Bronchoconstriction

Description

Abstract

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