Persulfidation is the mechanism underlying sulfide-signaling of autophagy

Description

In this commentary, we highlight the findings described in a recent paper regarding the mechanism of H2S regulation of macroautophagy/autophagy in mammalian cells and discuss the similarities/divergencies with plant cells. The main outcome is that the posttranslational modification of thiol groups of cysteine residues to form persulfides is a conserved molecular mechanism.

Abstract

Junta de Andalucía P18-RT-3154, US-1255781

Abstract

Marie Skłodowska-Curie 834120

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