Published 2021
| Version v1
Publication
SIRT6 enhances oxidative phosphorylation in breast cancer and promotes mammary tumorigenesis in mice
- Creators
- Becherini, Pamela
- Caffa, Irene
- Piacente, Francesco
- Damonte, Patrizia
- Vellone, Valerio G
- Passalacqua, Mario
- Benzi, Andrea
- Bonfiglio, Tommaso
- Reverberi, Daniele
- Khalifa, Amr
- Ghanem, Moustafa
- Guijarro, Ana
- Tagliafico, Luca
- Sucameli, Marzia
- Persia, Angelica
- Monacelli, Fiammetta
- Cea, Michele
- Bruzzone, Santina
- Ravera, Silvia
- Nencioni, Alessio
- Others:
- Becherini, Pamela
- Caffa, Irene
- Piacente, Francesco
- Damonte, Patrizia
- Vellone, Valerio G
- Passalacqua, Mario
- Benzi, Andrea
- Bonfiglio, Tommaso
- Reverberi, Daniele
- Khalifa, Amr
- Ghanem, Moustafa
- Guijarro, Ana
- Tagliafico, Luca
- Sucameli, Marzia
- Persia, Angelica
- Monacelli, Fiammetta
- Cea, Michele
- Bruzzone, Santina
- Ravera, Silvia
- Nencioni, Alessio
Description
Sirtuin 6 (SIRT6) is a NAD+-dependent deacetylase with key roles in cell metabolism. High SIRT6 expression is associated with adverse prognosis in breast cancer (BC) patients. However, the mechanisms through which SIRT6 exerts its pro-oncogenic effects in BC remain unclear. Here, we sought to define the role of SIRT6 in BC cell metabolism and in mouse polyoma middle T antigen (PyMT)-driven mammary tumors.
Additional details
- URL
- http://hdl.handle.net/11567/1038039
- URN
- urn:oai:iris.unige.it:11567/1038039
- Origin repository
- UNIGE