Sex differences in brain atrophy in dementia with Lewy bodies
- Creators
- Oltra J.
- Habich A.
- Schwarz C. G.
- Nedelska Z.
- Przybelski S. A.
- Inguanzo A.
- Diaz-Galvan P.
- Lowe V. J.
- Oppedal K.
- Gonzalez M. C.
- Philippi N.
- Blanc F.
- Barkhof F.
- Lemstra A. W.
- Hort J.
- Padovani A.
- Rektorova I.
- Bonanni L.
- Massa F.
- Kramberger M. G.
- Taylor J. -P.
- Snaedal J. G.
- Walker Z.
- Antonini A.
- Dierks T.
- Segura B.
- Junque C.
- Westman E.
- Boeve B. F.
- Aarsland D.
- Kantarci K.
- Ferreira D.
- Others:
- Oltra, J.
- Habich, A.
- Schwarz, C. G.
- Nedelska, Z.
- Przybelski, S. A.
- Inguanzo, A.
- Diaz-Galvan, P.
- Lowe, V. J.
- Oppedal, K.
- Gonzalez, M. C.
- Philippi, N.
- Blanc, F.
- Barkhof, F.
- Lemstra, A. W.
- Hort, J.
- Padovani, A.
- Rektorova, I.
- Bonanni, L.
- Massa, F.
- Kramberger, M. G.
- Taylor, J. -P.
- Snaedal, J. G.
- Walker, Z.
- Antonini, A.
- Dierks, T.
- Segura, B.
- Junque, C.
- Westman, E.
- Boeve, B. F.
- Aarsland, D.
- Kantarci, K.
- Ferreira, D.
Description
INTRODUCTION: Sex influences neurodegeneration, but it has been poorly investigated in dementia with Lewy bodies (DLB). We investigated sex differences in brain atrophy in DLB using magnetic resonance imaging (MRI). METHODS: We included 436 patients from the European-DLB consortium and the Mayo Clinic. Sex differences and sex-by-age interactions were assessed through visual atrophy rating scales (n = 327; 73 ± 8 years, 62% males) and automated estimations of regional gray matter volume and cortical thickness (n = 165; 69 ± 9 years, 72% males). RESULTS: We found a higher likelihood of frontal atrophy and smaller volumes in six cortical regions in males and thinner olfactory cortices in females. There were significant sex-by-age interactions in volume (six regions) and cortical thickness (seven regions) across the entire cortex. DISCUSSION: We demonstrate that males have more widespread cortical atrophy at younger ages, but differences tend to disappear with increasing age, with males and females converging around the age of 75. Highlights: Male DLB patients had higher odds for frontal atrophy on radiological visual rating scales. Male DLB patients displayed a widespread pattern of cortical gray matter alterations on automated methods. Sex differences in gray matter measures in DLB tended to disappear with increasing age.
Additional details
- URL
- https://hdl.handle.net/11567/1205118
- URN
- urn:oai:iris.unige.it:11567/1205118
- Origin repository
- UNIGE