Coinfection with HIV and hepatitis C virus in 229 children and young adults living in Europe
- Creators
- Thorne, Claire
- Turkova, Anna
- Indolfi, Giuseppe
- Venturini, Elisabetta
- Giaquinto, Carlo
- Goetghebuer, Tessa
- Hainaut, Marc
- Van der Kelen, Evelyne
- Koenigs, Christoph
- Mantzsch, Kathleen
- Baumann, Ulrich
- de Martino, Maurizio
- Galli, Luisa
- Giacomet, Vania
- Nicolini, Laura Ambra
- DEL PUENTE, FILIPPO
- Gabiano, Clara
- Guarino, Alfredo
- Martinazzi, Silvia
- Miniaci, Angela
- Dobsz, Sabina
- Marczynska, Magdalena
- Ene, Luminita
- Duiculescu, Dan
- Miloenko, Milana
- Dodonov, Konstantin
- Latysheva, Inga
- Voronin, Evgeny
- Rojo, Pablo
- Tomas Ramos, Jose
- Navarro, Marisa
- Jimenez de Ory, Santiago
- Sainz, Talia
- Mellado, Maria J
- Garcia, Miluca
- Perez, Carlos
- Moreno, David
- Nunez, Esmeralda
- Gracia, Mercedes
- Terol, Pedro
- Neth, Olaf
- Falcon, Lola
- Otero, Carmen
- Rincon, Elena
- Lopez, Carmen
- Luis Santos, Juan
- Couceiro, Jose
- Noguera-Julian, Antoni
- Fortuny, Claudia
- Soler-Palacin, Pere
- Espiau, Maria
- Mur, Antonio
- Coll, Maria T.
- Valmanya, Maria T.
- Mayol, Luis
- Mendez, Maria J.
- Rodrigo, Carlos
- Escribano, Joaquin
- Rius, Neus
- Rovira, Nuria
- Calavia, Olga
- Garcia, Lourdes
- Pineda, Valenti
- Soriano-Arandes, Antoni
- Rudin, Christoph
- Duppenthaler, Andrea
- Judd, Ali
- Malyuta, Ruslan
- Volokha, Alla
- Raus, Irina
- Kaleeva, T.
- Baryshnikova, Y.
- Soloha, Svetlana
- Bashkatova, N.
- Glutshenko, O
- Ruban, Z
- Primak, Natalia
- Kiseleva, Galina
- Others:
- Thorne, Claire
- Turkova, Anna
- Indolfi, Giuseppe
- Venturini, Elisabetta
- Giaquinto, Carlo
- Goetghebuer, Tessa
- Hainaut, Marc
- Van der Kelen, Evelyne
- Koenigs, Christoph
- Mantzsch, Kathleen
- Baumann, Ulrich
- de Martino, Maurizio
- Galli, Luisa
- Giacomet, Vania
- Nicolini, Laura Ambra
- DEL PUENTE, Filippo
- Gabiano, Clara
- Guarino, Alfredo
- Martinazzi, Silvia
- Miniaci, Angela
- Dobsz, Sabina
- Marczynska, Magdalena
- Ene, Luminita
- Duiculescu, Dan
- Miloenko, Milana
- Dodonov, Konstantin
- Latysheva, Inga
- Voronin, Evgeny
- Rojo, Pablo
- Tomas Ramos, Jose
- Navarro, Marisa
- Jimenez de Ory, Santiago
- Sainz, Talia
- Mellado, Maria J
- Garcia, Miluca
- Perez, Carlo
- Moreno, David
- Nunez, Esmeralda
- Gracia, Mercede
- Terol, Pedro
- Neth, Olaf
- Falcon, Lola
- Otero, Carmen
- Rincon, Elena
- Lopez, Carmen
- Luis Santos, Juan
- Couceiro, Jose
- Noguera-Julian, Antoni
- Fortuny, Claudia
- Soler-Palacin, Pere
- Espiau, Maria
- Mur, Antonio
- Coll, Maria T.
- Valmanya, Maria T.
- Mayol, Lui
- Mendez, Maria J.
- Rodrigo, Carlo
- Escribano, Joaquin
- Rius, Neu
- Rovira, Nuria
- Calavia, Olga
- Garcia, Lourde
- Pineda, Valenti
- Soriano-Arandes, Antoni
- Rudin, Christoph
- Duppenthaler, Andrea
- Judd, Ali
- Malyuta, Ruslan
- Volokha, Alla
- Raus, Irina
- Kaleeva, T.
- Baryshnikova, Y.
- Soloha, Svetlana
- Bashkatova, N.
- Glutshenko, O
- Ruban, Z
- Primak, Natalia
- Kiseleva, Galina
Description
Objective:To characterize children, adolescents and young adults infected with HIV/hepatitis C virus (HCV) vertically or before age of 18 years and living in Europe regarding mode of acquisition, HCV genotype, clinical status and treatment.Design:Retrospective, cross-sectional study using pooled data from 11 European paediatric HIV cohorts.Methods:Patients aged more than 18 months and less than 25 years, with HIV/HCV acquired vertically or in childhood, were included. Anonymized individual patient data were collected using a standard protocol and modified HIV Cohorts Data Exchange Protocol.Results:Of 229 patients included, 142 (62%) had vertically acquired infection. Median age at last follow-up was 16.2 years. Most children had HCV genotype 1 (101/184, 55%) or 3 (57/184, 31%). One-fifth (46/214) had a previous AIDS diagnosis (data missing on prior AIDS diagnoses for 15). At their last clinic visit, 70% (145/208) had no/mild immunosuppression (Centers for Disease Control and Prevention stage 1), and 131 of 179 on antiretroviral therapy had undetectable HIV RNA (assay thresholds varied from <20 to <150 copies/ml). Overall, 42% (86/204) had hepatomegaly in the previous year, and 55% (116/213) had alanine aminotransferase more than 40IU/l at their last test. Of 97 patients with transient elastography, 12 had results more than 9kPa; this was associated with duration of HCV infection (P=0.033), but not with CD4(+) cell count, antiretroviral therapy use or sex in univariable analysis. Of 17 patients with liver biopsies, six had bridging fibrosis and one had cirrhosis. Twenty-five (11%) had been treated successfully for HCV. Conclusion:The high proportion of patients with progressive liver disease underscores the need for close monitoring and earlier and more effective HCV treatment.
Additional details
- URL
- http://hdl.handle.net/11567/884435
- URN
- urn:oai:iris.unige.it:11567/884435
- Origin repository
- UNIGE