Impact of COVID-19 on pregnancy and fetal outcomes in women with multiple sclerosis
- Creators
- Aprea, Maria Grazia
- Schiavetti, Irene
- Portaccio, Emilio
- Ballerini, Chiara
- Bonavita, Simona
- Buscarinu, Maria
- Calabrese, Massimiliano
- Cavalla, Paola
- Cellerino, Maria
- Cordioli, Cinzia
- Dattola, Vincenzo
- De Biase, Stefano
- De Meo, Ermelinda
- Fantozzi, Roberta
- Gallo, Antonio
- Iasevoli, Luigi
- Karabudak, Rana
- Landi, Doriana
- Lorefice, Lorena
- Moiola, Lucia
- Ragonese, Paolo
- Ruscica, Francesca
- Sen, Sedat
- Sinisi, Leonardo
- Signoriello, Elisabetta
- Toscano, Simona
- Verrengia, Elena
- Siva, Aksel
- Masciulli, Camilla
- Sormani, Maria Pia
- Amato, Maria Pia
- Others:
- Aprea, Maria Grazia
- Schiavetti, Irene
- Portaccio, Emilio
- Ballerini, Chiara
- Bonavita, Simona
- Buscarinu, Maria
- Calabrese, Massimiliano
- Cavalla, Paola
- Cellerino, Maria
- Cordioli, Cinzia
- Dattola, Vincenzo
- De Biase, Stefano
- De Meo, Ermelinda
- Fantozzi, Roberta
- Gallo, Antonio
- Iasevoli, Luigi
- Karabudak, Rana
- Landi, Doriana
- Lorefice, Lorena
- Moiola, Lucia
- Ragonese, Paolo
- Ruscica, Francesca
- Sen, Sedat
- Sinisi, Leonardo
- Signoriello, Elisabetta
- Toscano, Simona
- Verrengia, Elena
- Siva, Aksel
- Masciulli, Camilla
- Sormani, Maria Pia
- Amato, Maria Pia
Description
Background: In the general population, maternal COVID-19 is associated with worse maternal and fetal outcomes. Two previous studies have assessed COVID-19 clinical outcomes in pregnant women with multiple sclerosis (MS), but there are no data about maternal and fetal outcomes.Objectives: In this multicenter study, we aimed to assess maternal and fetal outcomes in pregnant women with MS and COVID-19 infection.Methods: We recruited pregnant patients with MS who contracted COVID-19 and were followed up in Italian and Turkish Centers, during 2020-2022. A control group was extracted from a previous Italian cohort. Associations between group (COVID-19 or healthy patients) and clinical outcomes (maternal complications, fetal malformations, and spontaneous abortion) were investigated with a weighted logistic regression where propensity score-based inverse probability of treatment weighting (IPTW) approach was applied for adjusting for difference in baseline confounders.Results: In the multivariable analysis, COVID-19 during pregnancy was associated with a higher risk of maternal complications (odd ratio (OR) = 2.12; 95% confidence interval (CI) = 1.32-3.48; p = 0.002), while it was not associated with higher risk of spontaneous abortion and fetal malformations.Conclusion: Our data indicate that COVID-19 during pregnancy increases the risk of maternal complications, while it seems to have no significant impact on fetal outcomes.
Additional details
- URL
- https://hdl.handle.net/11567/1219834
- URN
- urn:oai:iris.unige.it:11567/1219834
- Origin repository
- UNIGE