Published 2015
| Version v1
Publication
DNMT3A moderates cognitive decline in subjects with mild cognitive impairment: Replicated evidence from two mild cognitive impairment cohorts
Creators
- Chouliaras, Leonidas
- Kenis, Gunter
- Visser, Pieter Jelle
- Scheltens, Philip
- Tsolaki, Magda
- Jones, Roy W.
- Kehoe, Patrick G.
- Graff, Caroline
- GIRTLER, NICOLA GIOVANNI
- Wallin, Åsa K.
- Rikkert, Marcel Olde
- Spiru, Luiza
- Elias Sonnenschein, Lyzel S.
- Ramakers, Inez H. G.
- Pishva, Ehsan
- Os, Jim Van
- Steinbusch, Harry W.
- Verhey, Frans R. J.
- Van Den Hove, Daniel L. A.
- Rutten, Bart P. F.
Contributors
Others:
- Chouliaras, Leonida
- Kenis, Gunter
- Visser, Pieter Jelle
- Scheltens, Philip
- Tsolaki, Magda
- Jones, Roy W.
- Kehoe, Patrick G.
- Graff, Caroline
- Girtler, NICOLA GIOVANNI
- Wallin, Åsa K.
- Rikkert, Marcel Olde
- Spiru, Luiza
- Elias Sonnenschein, Lyzel S.
- Ramakers, Inez H. G.
- Pishva, Ehsan
- Os, Jim Van
- Steinbusch, Harry W.
- Verhey, Frans R. J.
- Van Den Hove, Daniel L. A.
- Rutten, Bart P. F.
Description
Epigenetic dysregulation has been associated with cognitive decline and Alzheimer's disease. The present study investigated associations between common SNPs in genes regulating DNA methylation and age-related changes in cognitive decline in two independent prospective cohorts of patients suffering from mild cognitive impairment. An association between the rs1187120 SNP in DNMT3A and annual decline in cognitive functioning was discovered and replicated, suggesting that DNMT3A moderates cognitive decline in subjects with mild cognitive impairment.
Additional details
Identifiers
- URL
- http://hdl.handle.net/11567/861484
- URN
- urn:oai:iris.unige.it:11567/861484
Origin repository
- Origin repository
- UNIGE