Published May 21, 2021
| Version v1
Publication
Impact of treating asymptomatic bacteriuria in kidney transplant recipients: a prospective cohort study
Contributors
Description
This study aims to define the epidemiologic, clinical, and microbiological features of
asymptomatic bacteriuria (AB) and cystitis in kidney transplantation recipients (KTRs), and to
determine the impact of antimicrobial therapy of AB and the risk factors of cystitis. We conducted a
prospective observational study of AB and cystitis in KTRs from January to June 2017. One-hundred
ninety seven KTRs were included: 175 (88.8%) with AB and 22 (11.2%) with cystitis. The most frequent
etiologies were Escherichia coli, Klebsiella pneumoniae, Enterococcus faecalis, and Pseudomonas aeruginosa.
No differences were observed regarding the etiologies, antimicrobial susceptibility patterns, and
microbiologic outcomes in AB vs. cystitis. The treatment of AB diminished the microbiological cure
and increased the rates of microbiologic relapses and reinfections; in addition, treated AB patients
showed a trend of developing symptomatic urinary tract infection in the following six months. The
analysis of the data identified the following independent risk factors for cystitis during the six months
of follow-up: AB treatment, thymoglobulin induction, previous acute pyelonephritis, and time since
transplantation < 1 year. In summary, considering the lack of clinical benefits of treating AB and its
impact on cystitis development in the follow-up, we support the recommendation of not screening
for or treating AB.
Abstract
Instituto de Salud Carlos III, Subdirección General de Evaluación y Fomento de la Investigación, Ministerio de Economía, Industria y Competitividad PI17-01405Abstract
Plan Nacional de I + D + i 2013-2016Abstract
Instituto de Salud Carlos III, Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Ciencia, Innovación y Universidades, Red Española de Investigación en Enfermedades Infecciosas REIPI RD16 / 0016/0009Abstract
Cofinanciada por el Fondo Regional de Desarrollo Europeo 2014-2020. G.M.-G.Abstract
Contrato de Acceso al Sistema Español de Investigación e Innovación, V Programa de Investigación de la Universidad de Sevilla USE13901-DAdditional details
Identifiers
- URL
- https://idus.us.es/handle//11441/109148
- URN
- urn:oai:idus.us.es:11441/109148