Microwave-assisted synthesis of bioactive six-membered heterocycles and their fused analogues

Creators: Driowya, Mohsine; Saber, Aziza; Marzag, Hamid; Demange, Luc; Benhida, Rachid; Bougrin, Khalid

Others:: Laboratoire de Chimie des Plantes et de Synthèse Organique et Bioorganique ; Université Mohammed V de Rabat [Agdal] (UM5); Institut de Chimie de Nice (ICN) ; Université Nice Sophia Antipolis (1965 - 2019) (UNS) ; COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA); Université Paris Descartes - Faculté de Pharmacie de Paris (UPD5 Pharmacie) ; Université Paris Descartes - Paris 5 (UPD5)

Description

This review describes the formation of six-membered heterocyclic compounds and their fused analogues under microwave activation using modern organic transformations including cyclocondensation, cycloaddition, multicomponents and other modular reactions. The review is divided according to the main heterocycle types in order of increasing complexity, starting with heterocyclic systems containing one, two and three heteroatoms and their fused analogues. Recent microwave applications are reviewed, with special focus on the chemistry of bioactive compounds. Selected examples from the 2006 to 2015 literature are discussed.

Abstract

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Microwave-assisted synthesis of bioactive six-membered heterocycles and their fused analogues

Description

Abstract

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