Use of first-generation HCV protease inhibitors in patients coinfected by HIV and HCV genotype 1
- Others:
- Université Paris Descartes - Paris 5 (UPD5)
- AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris] ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)
- CHU Pontchaillou [Rennes]
- Hôpital Saint Joseph
- Université Pierre et Marie Curie - Paris 6 (UPMC)
- CHU Pitié-Salpêtrière [AP-HP] ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)
- Hôpital Européen Georges Pompidou [APHP] (HEGP) ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)
- CHU Saint-Antoine [AP-HP] ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)
- Université Montpellier 1 (UM1)
- Centre Hospitalier Universitaire de Montpellier (CHU Montpellier )
- CHU Tenon [AP-HP] ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)
- Agroécologie [Dijon] ; Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement
- Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon)
- Hôpital Sainte-Marguerite [CHU - APHM] (Hôpitaux Sud )
- Université de Nice Sophia-Antipolis (UNSA)
- Hôpital de l'Archet 2
Description
In HCV genotype 1-infected patients with HIV co-infection, tritherapy [HCV protease inhibitors (PIs) plus peg-interferon and ribavirin] has been shown to have an increased rate of sustained virological response. However, complex drug-to-drug interactions and tolerability issues remain a concern. Methods: Under the auspices of four French scientific societies of medicine, a committee was charged of establishing guidelines on the use of first-generation HCV PIs in these patients. This scientific committee based its work on preliminary results from tritherapy clinical trials in co-infected patients and, since data on these patients are still scarce, on the statements already made by the French Association for the Study of the Liver (AFEF) on the use of tritherapy in HCV mono-infected patients, written in May 2011 and updated in 2012. Each AFEF guideline concerning HCV monoinfection was examined to determine whether it could be used in the context of HIV/HCV coinfection. Results: These guidelines are addressed for the treatment of coinfected patients with various profiles, including treatment-naive or patients with failure to previous bitherapy and mention those patients for whom tritherapy should start or those for whom it should be delayed. Preliminary results of triple therapy as well as factors associated to virological response are also discussed. Other issues include virological monitoring, clinical and virological criteria to stop therapy, practical treatment management, treatment adherence and the management of side effects and interactions with antiretroviral drugs. These guidelines were submitted for critical review to independent experts.
Abstract
EA MERS
Abstract
International audience
Additional details
- URL
- https://hal.inrae.fr/hal-02637829
- URN
- urn:oai:HAL:hal-02637829v1
- Origin repository
- UNICA