Comparative effectiveness of antiepileptic drugs in patients with mesial temporal lobe epilepsy with hippocampal sclerosis
- Creators
- Androsova G.
- Krause R.
- Borghei M.
- Wassenaar M.
- Auce P.
- Avbersek A.
- Becker F.
- Berghuis B.
- Campbell E.
- Coppola A.
- Francis B.
- Wolking S.
- Cavalleri G. L.
- Craig J.
- Delanty N.
- Koeleman B. P. C.
- Kunz W. S.
- Lerche H.
- Marson A. G.
- Sander J. W.
- Sills G. J.
- Striano P.
- Zara F.
- Sisodiya S. M.
- Depondt C.
- Brodie M. J.
- Chinthapalli K.
- de Haan G. -J.
- Doherty C.
- Gudmundsson L. J.
- Heavin S.
- Ingason A.
- Johnson M.
- Kennedy C.
- Krenn M.
- McCormack M.
- O'Brien T. J.
- Pandolfo M.
- Pataraia E.
- Petrovski S.
- Rau S.
- Sargsyan N.
- Slattery L.
- Stefansson K.
- Stern W.
- Tostevin A.
- Willis J.
- Zimprich F.
- Others:
- Androsova, G.
- Krause, R.
- Borghei, M.
- Wassenaar, M.
- Auce, P.
- Avbersek, A.
- Becker, F.
- Berghuis, B.
- Campbell, E.
- Coppola, A.
- Francis, B.
- Wolking, S.
- Cavalleri, G. L.
- Craig, J.
- Delanty, N.
- Koeleman, B. P. C.
- Kunz, W. S.
- Lerche, H.
- Marson, A. G.
- Sander, J. W.
- Sills, G. J.
- Striano, P.
- Zara, F.
- Sisodiya, S. M.
- Depondt, C.
- Brodie, M. J.
- Chinthapalli, K.
- de Haan, G. -J.
- Doherty, C.
- Gudmundsson, L. J.
- Heavin, S.
- Ingason, A.
- Johnson, M.
- Kennedy, C.
- Krenn, M.
- Mccormack, M.
- O'Brien, T. J.
- Pandolfo, M.
- Pataraia, E.
- Petrovski, S.
- Rau, S.
- Sargsyan, N.
- Slattery, L.
- Stefansson, K.
- Stern, W.
- Tostevin, A.
- Willis, J.
- Zimprich, F.
Description
Objective: Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) is a common epilepsy syndrome that is often poorly controlled by antiepileptic drug (AED) treatment. Comparative AED effectiveness studies in this condition are lacking. We report retention, efficacy, and tolerability in a cohort of patients with MTLE-HS. Methods: Clinical data were collected from a European database of patients with epilepsy. We estimated retention, 12-month seizure freedom, and adverse drug reaction (ADR) rates for the 10 most commonly used AEDs in patients with MTLE-HS. Results: Seven hundred sixty-seven patients with a total of 3,249 AED trials were included. The highest 12-month retention rates were observed with carbamazepine (85.9%), valproate (85%), and clobazam (79%). Twelve-month seizure freedom rates varied from 1.2% for gabapentin and vigabatrin to 11% for carbamazepine. Response rates were highest for AEDs that were prescribed as initial treatment and lowest for AEDs that were used in a third or higher instance. ADRs were reported in 47.6% of patients, with the highest rates observed with oxcarbazepine (35.7%), topiramate (30.9%), and pregabalin (27.4%), and the lowest rates with clobazam (6.5%), gabapentin (8.9%), and lamotrigine (16.6%). The most commonly reported ADRs were lethargy and drowsiness, dizziness, vertigo and ataxia, and blurred vision and diplopia. Significance: Our results did not demonstrate any clear advantage of newer versus older AEDs. Our results provide useful insights into AED retention, efficacy, and ADR rates in patients with MTLE-HS.
Additional details
- URL
- http://hdl.handle.net/11567/1022135
- URN
- urn:oai:iris.unige.it:11567/1022135
- Origin repository
- UNIGE