Published December 1, 2010
| Version v1
Journal article
Decrease of prefrontal metabolism after subthalamic stimulation in obsessive-compulsive disorder: a positron emission tomography study.
Creators
- Le Jeune, Florence
- Vérin, Marc
- N'Diaye, Karim
- Drapier, Dominique
- Leray, Emmanuelle
- Du Montcel, Sophie Tezenas
- Baup, Nicolas
- Pelissolo, Antoine
- Polosan, Mircea
- Mallet, Luc
- Yelnik, Jérome
- Devaux, Bertrand
- Fontaine, Denys
- Chereau, Isabelle
- Bourguignon, Aurélie
- Peron, Julie
- Sauleau, Paul
- Raoul, Sylvie
- Garin, Etienne
- Krebs, Marie-Odile
- Jaafari, Nematollah
- Millet, Bruno
Contributors
Others:
- Département de médecine nucléaire [Rennes] ; CRLCC Eugène Marquis (CRLCC)
- Comportement et noyaux gris centraux = Behavior and Basal Ganglia [Rennes] ; Université de Rennes (UR)-Université européenne de Bretagne - European University of Brittany (UEB)-Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital-Institut des Neurosciences Cliniques de Rennes = Institute of Clinical Neurosciences of Rennes (INCR)
- Service de Neurologie [Rennes] = Neurology [Rennes] ; Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital
- Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière (CRICM) ; Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
- Service de psychiatrie ; Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital-Hôpital Guillaume Régnier
- Service de santé publique et d'épidémiologie ; Hôpital Pontchaillou-Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital
- CHU Pitié-Salpêtrière [AP-HP] ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)
- Service de psychiatrie ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Hôpital Sainte-Anne
- CIC AP-HP (pitie-Salpetriere)/inserm ; Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)
- ANTE-INSERM U836, équipe 11, Fonctions cérébrales et neuromodulation ; Service de psychiatrie ; CHU Grenoble-CHU Grenoble
- Service de Neurochirurgie ; Centre Hospitalier Universitaire de Nice (CHU Nice)
- Service de psychiatrie ; CHU Clermont-Ferrand
- Service de physiologie ; Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital
- Service de neurochirurgie
- CIC - Poitiers ; Université de Poitiers-Centre hospitalier universitaire de Poitiers (CHU Poitiers)-Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale (INSERM)
- This study was supported by a grant from Medtronic to Dr. Millet.
- French Stimulation dans le trouble obsessionnel compulsif (STOC) study group
Description
BACKGROUND: High-frequency bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) is a promising treatment in refractory obsessive-compulsive disorder (OCD). METHOD: Using the crossover, randomized, and double-blind procedure adopted by the STOC study, 10 patients treated with high-frequency bilateral STN DBS underwent am 18-fluorodeoxyglucose positron emission tomography (PET) investigation to highlight the neural substratum of this therapeutic approach. RESULTS: The median Yale-Brown Obsessive Compulsive Scale (Y-BOCS) scores for all 10 patients were 31 (minimum = 18, maximum = 36) with "Off-Stimulation" status and 19 (minimum = 0, maximum = 30) with "On-Stimulation" status (p = .05). The OCD patients in Off-Stimulation status showed a hypermetabolism in the right frontal middle and superior gyri, right parietal lobe, postcentral gyrus, and bilateral putamen compared with healthy control subjects. A significant decrease in cerebral metabolism was observed in the left cingulate gyrus and the left frontal medial gyrus in On-Stimulation conditions compared with Off-Stimulation conditions. In addition, the improvement assessed by Y-BOCS scores during the On-Stimulation conditions was positively correlated with PET signal changes at the boundary of the orbitofrontal cortex and the medial prefrontal cortex, between PET signal changes and the Y-BOCS scores modifications in On-Stimulation status. CONCLUSION: This study suggests that the therapeutic effect of STN DBS is related to a decrease in prefrontal cortex metabolism.
Abstract
International audienceAdditional details
Identifiers
- URL
- https://inserm.hal.science/inserm-00667511
- URN
- urn:oai:HAL:inserm-00667511v1
Origin repository
- Origin repository
- UNICA