Oxidized Low-Density Lipoproteins Induce Tissue Factor Expression in T-Lymphocytes via activation of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1

Creators: Cimmino, Giovanni; Cirillo, Plinio; Conte, Stefano; Pellegrino, Grazia; Barra, Giusi; Maresca, Lucio; Morello, Andrea; Calì, Gaetano; Loffredo, Francesco; De Palma, Raffaele; Arena, Giulia; Sawamura, Tatsuya; Ambrosio, Giuseppe; Golino, Paolo

Others:: Cimmino, Giovanni; Cirillo, Plinio; Conte, Stefano; Pellegrino, Grazia; Barra, Giusi; Maresca, Lucio; Morello, Andrea; Calì, Gaetano; Loffredo, Francesco; De Palma, Raffaele; Arena, Giulia; Sawamura, Tatsuya; Ambrosio, Giuseppe; Golino, Paolo

Description

T-lymphocytes plays an important role in the pathophysiology of acute coronary syndromes (ACS). T-cell activation in vitro by pro-inflammatory cytokines may lead to functional Tissue Factor (TF) expression, indicating a possible contribution of immunity to thrombosis. Oxidized low-density lipoproteins (oxLDLs) are found abundantly in atherosclerotic plaques. We aimed at evaluating the effects of oxLDLs on TF expression in T-cells and the role of the lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1).

Oxidized Low-Density Lipoproteins Induce Tissue Factor Expression in T-Lymphocytes via activation of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1

Description

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